Thermo Fisher Scientific IGFBP3 Monoclonal Antibody (IGFBP3/3424)
인슐린 유사 성장인자 결합 단백질 IGFBP3를 인식하는 Mouse 모노클로날 항체. 인간 시료 반응성, ICC/IF 및 Flow Cytometry 등 다양한 응용 가능. 단백질 A/G 정제, 4°C 보관, 연구용 전용.
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Thermo Fisher Scientific IGFBP3 Monoclonal Antibody (IGFBP3/3424)
Applications and Tested Dilution
| Application | Tested Dilution |
|---|---|
| Immunocytochemistry (ICC/IF) | 1–2 µg/mL |
| Flow Cytometry (Flow) | 1–2 µg/10^6 cells |
| Peptide Array (Array) | Assay-dependent |
Product Specifications
| Specification | Description |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Mouse / IgG2b, kappa |
| Class | Monoclonal |
| Type | Antibody |
| Clone | IGFBP3/3424 |
| Immunogen | Recombinant human full-length IGFBP3 protein |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 200 µg/mL |
| Purification | Protein A/G |
| Storage Buffer | PBS with 0.05% BSA |
| Contains | 0.05% sodium azide |
| Storage Conditions | 4°C |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
Product Specific Information
- Antibody is stable for 24 months.
- Positive Control: U-87 or A-431 cells
- Cellular Localization: Secreted; localized to vesicles, cytosol, and nucleoplasm.
Specificity Comments:
The Insulin-like growth factor-binding proteins (IGFBPs) are a family of homologous proteins that co-evolved with IGFs. They act as shuttle molecules for soluble IGFs and regulate IGF signaling. IGFBP3 is the most abundant IGFBP, complexed with approximately 80% of serum IGFs. Both IGFBP3 and IGFBP4 are released by dermal fibroblasts in response to incision injury.
Target Information
IGFBP3 belongs to the insulin-like growth factor binding protein (IGFBP) family. It encodes a protein containing both an IGFBP domain and a thyroglobulin type-I domain. IGFBP3 forms a ternary complex with IGFALS and IGF I or II, circulating in plasma to prolong IGF half-life and modulate receptor interaction. Several isoforms exist due to alternative splicing.
Diseases associated with IGFBP3: Insulin-Like Growth Factor I and Acid-Labile Subunit Deficiency.
For Research Use Only.
Not for use in diagnostic procedures. Not for resale without express authorization.
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