Thermo Fisher Scientific mGluR8 Polyclonal Antibody
Rabbit polyclonal antibody targeting human mGluR8 (GRM8), validated for WB and IHC(P). Detects endogenous mGluR8 levels. Supplied as liquid form, 1 mg/mL, affinity purified, stored at -20°C. For research use only.
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Applications
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1:500–1:2,000 |
| Immunohistochemistry (Paraffin) (IHC (P)) | 1:50–1:200 |
Product Specifications
| Property | Description |
|---|---|
| Species Reactivity | Human, Mouse, Rat |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | A synthesized peptide derived from human GRM8 (Accession O00222), corresponding to amino acid residues R852–S902 |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Affinity chromatography |
| Storage Buffer | PBS, pH 7.4, with 50% glycerol |
| Contains | 0.02% sodium azide |
| Storage Conditions | -20°C |
| Shipping Conditions | Wet ice |
| RRID | AB_2903100 |
Product Specific Information
Antibody detects endogenous levels of total mGluR8.
Target Information
L-glutamate is the major excitatory neurotransmitter in the central nervous system and activates both ionotropic and metabotropic glutamate receptors. Glutamatergic neurotransmission is involved in most aspects of normal brain function and can be perturbed in many neuropathologic conditions.
The metabotropic glutamate receptors are a family of G protein-coupled receptors divided into three groups based on sequence homology, signal transduction mechanisms, and pharmacologic properties.
- Group I: GRM1, GRM5 – activate phospholipase C
- Group II: GRM2, GRM3
- Group III: GRM4, GRM6, GRM7, GRM8
Groups II and III are linked to inhibition of the cyclic AMP cascade but differ in agonist selectivities.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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