Thermo Fisher Scientific MCK10 Polyclonal Antibody
MCK10(DDR1) 단백질을 인식하는 Rabbit Polyclonal 항체로, WB 및 IHC(P) 적용 가능. Human 및 Mouse 반응성 확인됨. 항원 친화 크로마토그래피로 정제되어 높은 특이도 제공. 연구용으로 세포 부착 및 이동 관련 연구에 적합.
- 카탈로그번호
- PA529316
- 판매단위
- pk
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Applications
| Application | Tested Dilution | Publications |
|---|---|---|
| Western Blot (WB) | 1:1,000–1:10,000 | - |
| Immunohistochemistry (IHC) | - | 1 publication |
| Immunohistochemistry (Paraffin) (IHC (P)) | 1:100–1:1,000 | 1 publication |
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human, Mouse |
| Published Species | Mouse |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Recombinant fragment corresponding to a region within amino acids 138–395 of Human DDR1 |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Antigen affinity chromatography |
| Storage Buffer | 0.1M Tris Glycine, pH 7, with 10% glycerol |
| Contains | 0.01% thimerosal |
| Storage Conditions | Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles. |
| Shipping Conditions | Wet ice |
| RRID | AB_2546792 |
Product Specific Information
- Recommended positive controls: A431, H1299, HeLa, HepG2, Raji, mouse brain
- Predicted reactivity: Mouse (89%), Rat (91%), Pig (93%), Rhesus Monkey (99%), Chimpanzee (100%), Bovine (91%)
- Store product as a concentrated solution. Centrifuge briefly prior to opening the vial.
Target Information
DDR1 is a receptor tyrosine kinase activated by collagen and is reported to regulate adhesion, cell migration, and other cellular processes.
Receptor tyrosine kinases (RTKs) play a key role in cellular communication, growth, differentiation, and metabolism.
The encoded protein is widely expressed in normal and transformed epithelial cells and is activated by various types of collagen.
It belongs to a subfamily of tyrosine kinase receptors with homology to the Dictyostelium discoideum discoidin I protein in their extracellular domain.
Autophosphorylation occurs in response to all tested collagens (types I–VI).
Expression is primarily in epithelial cells of kidney, lung, gastrointestinal tract, and brain, and is overexpressed in several human tumors (breast, ovarian, esophageal, pediatric brain).
The gene is located on chromosome 6p21.3 near HLA class I genes and undergoes alternative splicing resulting in multiple transcript variants.
⚠ WARNING: This product can expose you to chemicals including mercury, which is known to the State of California to cause birth defects or other reproductive harm.
For more information, visit www.P65Warnings.ca.gov.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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