Thermo Fisher Scientific MCK10 Polyclonal Antibody

Applications

Product Specifications

Product Specific Information

• Recommended positive controls: A431, H1299, HeLa, HepG2, Raji, mouse brain
• Predicted reactivity: Mouse (89%), Rat (91%), Pig (93%), Rhesus Monkey (99%), Chimpanzee (100%), Bovine (91%)
• Store product as a concentrated solution. Centrifuge briefly prior to opening the vial.

Target Information

DDR1 is a receptor tyrosine kinase activated by collagen and is reported to regulate adhesion, cell migration, and other cellular processes.
Receptor tyrosine kinases (RTKs) play a key role in cellular communication, growth, differentiation, and metabolism.
The encoded protein is widely expressed in normal and transformed epithelial cells and is activated by various types of collagen.
It belongs to a subfamily of tyrosine kinase receptors with homology to the Dictyostelium discoideum discoidin I protein in their extracellular domain.
Autophosphorylation occurs in response to all tested collagens (types I–VI).
Expression is primarily in epithelial cells of kidney, lung, gastrointestinal tract, and brain, and is overexpressed in several human tumors (breast, ovarian, esophageal, pediatric brain).
The gene is located on chromosome 6p21.3 near HLA class I genes and undergoes alternative splicing resulting in multiple transcript variants.

⚠ WARNING: This product can expose you to chemicals including mercury, which is known to the State of California to cause birth defects or other reproductive harm.
For more information, visit www.P65Warnings.ca.gov.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.