Thermo Fisher Scientific CD25/IL2RA (Activated Lymphocyte Marker) Monoclonal Antibody (IL2RA/2394)
인간 CD25/IL2RA를 특이적으로 인식하는 Mouse monoclonal antibody로, 활성화된 림프구 마커 연구에 적합합니다. IHC 및 Peptide Array에 사용 가능하며, 고순도 Protein A/G 정제 및 안정적인 PBS buffer로 제공됩니다. 연구용으로만 사용됩니다.
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Applications and Tested Dilution
| Application | Tested Dilution |
|---|---|
| Immunohistochemistry (Paraffin) (IHC (P)) | Assay-dependent |
| Immunohistochemistry (PFA fixed) (IHC (PFA)) | 1–2 µg/mL |
| Peptide Array (Array) | Assay-dependent |
Product Specifications
| Specification | Details |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Mouse / IgG2b, kappa |
| Class | Monoclonal |
| Type | Antibody |
| Clone | IL2RA/2394 |
| Immunogen | Recombinant human IL2RA protein fragment (around aa 42–183) |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 200 µg/mL |
| Purification | Protein A/G |
| Storage Buffer | PBS, pH 7.4, with 0.05% BSA |
| Contains | 0.05% sodium azide |
| Storage Conditions | 4°C, do not freeze |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
Target Information
CD25 (IL2 receptor alpha chain/IL2RA) is a cytokine receptor involved in T and B lymphocyte proliferation. IL2RA forms a heterotrimeric complex with IL2RB and IL2RG to create the high-affinity IL2 receptor. Homodimeric IL2RA chains yield low-affinity receptors, while IL2RB homodimers produce medium-affinity receptors. IL2 expression in mature thymocytes is monoallelic, highlighting a unique gene expression regulation mechanism. IL2, produced mainly by mature T cells, functions as a growth and differentiation factor and regulates cell death. It enhances B cell proliferation, boosts NK cell activity, and inhibits granulocyte macrophage colony formation. Disruption of a similar gene in mice results in ulcerative colitis-like disease, indicating its importance in immune response regulation. Mutations in this gene are linked to interleukin 2 receptor alpha deficiency.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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