Thermo Fisher Scientific Phospho-P53 (Ser392) Polyclonal Antibody
인간 및 생쥐 p53 단백질의 Ser392 인산화 부위를 인식하는 rabbit polyclonal antibody. WB, IHC, ICC, ELISA 등 다양한 응용 가능. Protein A로 정제된 액상 형태이며, -20°C 보관. 세포 스트레스 및 종양 형성과 관련된 p53 연구에 적합.
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Thermo Fisher Scientific Phospho-P53 (Ser392) Polyclonal Antibody
Applications and Tested Dilution
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1:500–1:2,000 |
| Immunohistochemistry (Paraffin) (IHC-P) | 1:100–1:500 |
| Immunohistochemistry (Frozen) (IHC-F) | 1:100–1:500 |
| Immunocytochemistry (ICC/IF) | 1:100–1:500 |
| ELISA | 1:500–1:1,000 |
Product Specifications
| Specification | Description |
|---|---|
| Species Reactivity | Human, Mouse |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | KLH conjugated synthetic phosphopeptide derived from human p53 around the phosphorylation site of Ser392 |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Protein A |
| Storage Buffer | 0.01M TBS, pH 7.4, with 50% glycerol, 1% BSA |
| Contains | 0.02% ProClin 300 |
| Storage Conditions | -20°C |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
Target Information
The tumor suppressor protein p53 is a sequence-specific transcription factor activated by cellular stress. It mediates cell cycle arrest or apoptosis in response to DNA damage or pyrimidine nucleotide starvation. Upon stress, p53 activates transcription of specific genes such as p21waf1, regulating G1 or G2/M arrest. Structurally, p53 consists of an N-terminal transactivation domain, a central DNA-binding domain, an oligomerization domain, and a C-terminal regulatory domain.
Phosphorylation at Ser15 is critical for p53 activation and stabilization, while phosphorylation at Ser392 is associated with tumor formation. p53 also plays roles in aging, oxidative stress, and cognitive functions, with elevated levels linked to deficits in long-term potentiation (LTP). Normally expressed at low levels, p53 is upregulated in transformed cells, contributing to malignancy. Mutations in p53 disrupt DNA binding and tumor suppression, and alterations in the TP53 gene are found in both somatic and germline mutations, including Li-Fraumeni syndrome.
For Research Use Only. Not for use in diagnostic procedures or resale without authorization.
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