Thermo Fisher Scientific GRIK1 Polyclonal Antibody

Applications and Tested Dilutions

Product Specifications

Product Specific Information

• Suggested positive control: P815 cell lysate
• PA5-20447 can be used with blocking peptide PEP-0564
• Avoid prolonged exposure to high temperatures

Target Information

Glutamate receptors are the predominant excitatory neurotransmitter receptors in the mammalian brain and are activated in various normal neurophysiologic processes.
Grik1 (glutamate receptor 5) belongs to the kainate family of glutamate receptors, functioning as ligand-activated ion channels composed of four subunits.
Grik1 is expressed in GABAergic interneurons of the hippocampus and participates in forming various subtypes of kainate receptors with Grik2 and KA2.
Stimulation of Grik1 leads to intracellular calcium release and activation of protein kinase C. Excessive activation is associated with psychiatric, neurological, and neurodegenerative diseases.
Multiple isoforms of Grik1 exist and may undergo RNA editing within the second transmembrane domain, altering ion flow properties.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.