Thermo Fisher Scientific GUCY1B3 Polyclonal Antibody

Applications

Western Blot (WB)

• Tested Dilution: 0.2–1 µg/mL

Product Specifications

Product Specific Information

Peptide sequence:
LIEEKESKEE DFYEDLDRFE ENGTQESRIS PYTFCKAFPF HIIFDRDLVV

Sequence homology:
Cow: 100%
Dog: 100%
Guinea Pig: 100%
Horse: 100%
Human: 100%
Mouse: 100%
Rabbit: 100%
Rat: 100%
Zebrafish: 92%

Target Information

Guanylate cyclases belong to the adenylyl cyclase class-4/guanylyl cyclase family.
There are two forms of guanylate cyclase: a soluble form (GCS or sGC), which acts as a receptor for nitric oxide, and a membrane-bound receptor form (GC), which serves as a peptide hormone receptor.

The GC-C protein is composed of:

• An extracellular domain
• A single transmembrane domain
• A cytoplasmic region consisting of a kinase-like domain and a catalytic domain

It is expressed as two differentially glycosylated forms:

• 130 kDa precursor form (endoplasmic reticulum)
• 145 kDa form (plasma membrane)

Ligand binding to the extracellular domain of GC-C promotes cGMP accumulation.
GC-C acts as the receptor for heat-stable enterotoxins from pathogenic E. coli strains that cause severe secretory diarrhea.
It also binds to guanylin and uroguanylin peptides, which modulate renal function in response to oral salt load.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.