Thermo Fisher Scientific KPNA6 Polyclonal Antibody
Rabbit polyclonal antibody against human KPNA6, suitable for WB, IHC, ICC/IF, and ELISA. Recognizes KPNA6 involved in nuclear protein transport. Supplied as liquid at 1 mg/mL, stored at -20°C. For research use only.
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Applications and Tested Dilutions
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1:300 |
| Immunohistochemistry (Paraffin) (IHC-P) | 1:200–1:400 |
| Immunohistochemistry (Frozen) (IHC-F) | 1:100–1:500 |
| Immunocytochemistry (ICC/IF) | 1:100–1:500 |
| ELISA | 1:500–1:1,000 |
Product Specifications
| Specification | Description |
|---|---|
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | KLH-conjugated synthetic peptide derived from human KPNA6 |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Storage Conditions | -20°C |
| Shipping Conditions | Wet ice |
Target Information
Karyopherin is a cytosolic and heterodimeric protein complex consisting of alpha and beta subunits, responsible for targeting proteins with nuclear localization signals to the nuclear pore complex (NPC) through an energy-dependent, Ran-mediated mechanism. The alpha subunit and imported substrate enter the nucleus and accumulate in the nucleoplasm, while the beta subunit accumulates at the NPC.
KPNA6 belongs to a subfamily within the KPNA family that also includes IPOA5 and IPOA6. Down-regulation of KPNA6 by RNAi expression in HeLa cells strongly inhibited cell proliferation, possibly due to blocking the nuclear import of specific factors essential for cell growth and proliferation. KPNA6 also interacts with the Rev protein of HIV-1 and promotes its nuclear import.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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