Thermo Fisher Scientific Phospho-JIP1 (Thr103) Polyclonal Antibody
Phospho-JIP1 (Thr103) 특이적 Rabbit Polyclonal Antibody로, Western Blot 및 Immunocytochemistry에 사용 가능. 인간 JIP1의 Thr103 인산화 부위 유래 합성 인산화 펩타이드로 면역화. 1 mg/mL 액상 형태, -20°C 보관. 연구용으로만 사용.
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Applications
Western Blot (WB)
- Tested Dilution: 1:500–1:1,000
Immunocytochemistry (ICC/IF)
- Tested Dilution: 1:100–1:500
Product Specifications
| 항목 | 내용 |
|---|---|
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | A synthetic phosphopeptide derived from human JIP1 around the phosphorylation site of Thr103 (G-D-TP-P-G) |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Storage Conditions | -20°C |
| Shipping Conditions | Wet ice |
| RRID | AB_2555105 |
Target Information
The protein encoded by this gene regulates pancreatic beta-cell function and is highly similar to JIP-1, a mouse protein known to regulate c-Jun amino-terminal kinase (MAPK8). It prevents MAPK8-mediated activation of transcription factors and reduces IL-1β and MEKK1-induced apoptosis in pancreatic beta cells. Additionally, it functions as a DNA-binding transactivator of the glucose transporter GLUT2. REST represses its expression in insulin-secreting beta cells. Mutations in this gene have been associated with type 2 diabetes susceptibility.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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