Thermo Fisher Scientific NANOS3 Polyclonal Antibody
NANOS3 단백질을 검출하기 위한 Thermo Fisher Scientific의 Rabbit Polyclonal Antibody. Western blot 및 IHC(Paraffin) 실험에 적합하며, Human 및 Mouse 시료에서 반응. 고순도 Affinity chromatography 정제, 1 mg/mL 농도, 안정적 PBS/glycerol 보존.
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Applications
Western Blot (WB)
- Tested Dilution: 1:500–1:2,000
- Publications: References
Immunohistochemistry (Paraffin) (IHC (P))
- Tested Dilution: 1:50–1:200
- Publications: References
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human, Mouse |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | A synthesized peptide derived from human NANOS3 (Accession P60323), corresponding to amino acid residues Q114–S164 |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Affinity chromatography |
| Storage Buffer | PBS with 50% glycerol |
| Contains | 0.02% sodium azide |
| Storage Conditions | -20°C |
| Shipping Conditions | Wet ice |
| RRID | AB_2900250 |
Product Specific Information
Antibody detects endogenous levels of total Nanos3.
Target Information
Nanos is a zinc-finger containing, RNA-binding protein implicated in germ cell development in both invertebrates and vertebrates. In Drosophila, Nanos represses apoptosis during development to ensure proper germ-line formation. In mammals, Nanos2 and Nanos3 are essential for germ cell development, while Nanos1 expression is dispensable.
- Nanos2-deficient primordial germ cells (PGCs) die only in male gonads.
- Nanos3-deficient PGCs are lost during migration regardless of sex.
Distinct expression patterns of Nanos2 and Nanos3 suggest non-redundant functions, though Nanos2 expression can partially compensate for Nanos3 deficiency. Nanos3 expression cannot rescue Nanos2-deficient defects.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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