Thermo Fisher Scientific MARVELD2/Tricellulin Polyclonal Antibody
MARVELD2/Tricellulin 단백질을 인식하는 Rabbit Polyclonal 항체로, Western blot과 Immunoprecipitation에 적합. 상피세포의 삼중 세포 접합부 연구에 유용하며, 액상 형태로 4°C 보관. 연구용으로만 사용 가능.
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Applications
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1:2,000–1:10,000 |
| Immunoprecipitation (IP) | 2–5 µg/mg lysate |
Product Specifications
| 항목 | 내용 |
|---|---|
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Between amino acids 40 and 90 of human MARVELD2 (UniProt ID: Q8N4S9-1) |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 0.20 mg/mL |
| Storage Conditions | 4°C |
| Shipping Conditions | Wet ice |
Product Specific Information
The recommended shelf life for this product is 1 year from the date of receipt.
Target Information
Tight junctions form an important barrier for paracellular transport in epithelial cells. Tricellulin is the first protein identified that specifically concentrates in tricellular tight junctions — points where three adjacent cells meet. This protein has four membrane-spanning domains, similar to claudins. Tricellulin is highly expressed in epithelium-derived tissues such as the small intestine, kidney, and lung. Functional studies using siRNA show that suppression of tricellulin expression compromises epithelial barrier integrity and tight junction formation. Mutations affecting the cytosolic domain, which binds to the scaffolding protein ZO-1, suggest that interactions with other tight junction proteins are critical for tricellulin function.
For Research Use Only. Not for use in diagnostic procedures or resale without express authorization.
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