Thermo Fisher Scientific CDK8 Recombinant Rabbit Monoclonal Antibody (2P3P8)

Applications

Tested Dilution

Publications

Western Blot (WB)

1:1,000-1:5,000

-

ELISA (ELISA)

1 µg/mL

-

Product Specifications

Species Reactivity

Human, Mouse

Host/Isotype

Rabbit / IgG

Expression System

HEK293 cells

Class

Recombinant Monoclonal

Type

Antibody

Clone

2P3P8

Immunogen

Recombinant fusion protein containing a sequence corresponding to amino acids 364-464 of human CDK8. if (typeof window.$mangular === undefined || !window.$mangular) { window.$mangular = {}; } $mangular.antigenJson = \[{targetFamily:CDK8,uniProtId:P49336-1,ncbiNodeId:9606,antigenRange:364-464,antigenLength:464,antigenImageFileName:MA5-55259_CDK8_P49336-1_Rabbit.svg,antigenImageFileNamePDP:MA5-55259_CDK8_P49336-1_Rabbit_PDP.jpeg,sortOrder:1}\]; $mangular.isB2BCMGT = false; $mangular.isEpitopesModalImageMultiSizeEnabled = true;

View immunogen .st0{fill:#FFFFFF;} .st1{fill:#1E8AE7;}

Conjugate

Unconjugated Unconjugated Unconjugated

Form

Liquid

Concentration

1.18 mg/mL

Purification

Protein A

Storage buffer

PBS, pH 7.3, with 0.05% BSA, 50% glycerol

Contains

0.05% ProClin 300

Storage conditions

-20° C, Avoid Freeze/Thaw Cycles

Product Specific Information

Immunogen Sequence: PDDKGDKKNQ QQQQGNNHTN GTGHPGNQDS SHTQGPPLKK VRVVPPTTTS GGLIMTSDYQ RSNPHAAYPN PGPSTSQPQS SMGYSATSQQ PPQYSHQTHR Y

Target Information

CDK8 phosphorylates the carboxy-terminal domain of the largest subunit of RNA polymerase II. This protein is coexpressed and copurified with Cyclin C. CDK8 is part of a family of proteins designated as cdks are critical regulators of cell cycle progression. The prototype member of this family, p34/Cdc 2, and a related protein Cdk 2, function late in the cycle while Cdk 4 and Cdk 6 are critically involved in G1 to S progression. Because of analogy with yeast Cdk 8, it has been proposed that the human Cdk 8 Cyclin C may interact with RNA polymerase, thus influencing the transcription mechanism(s) that lead to cell division.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.