Thermo Fisher Scientific CD45RB (B-Cell Marker) Monoclonal Antibody (DF-B1)
CD45RB 단백질을 표적하는 인간 반응성 Mouse IgG3 단클론 항체로, IHC, ICC/IF, Flow Cytometry 등에 사용 가능. 단백질 A/G로 정제된 액상 형태이며, 보존제 무첨가 PBS 용액으로 제공. 연구용으로만 사용.
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Applications and Tested Dilution
| Application | Tested Dilution |
|---|---|
| Immunohistochemistry (Paraffin) (IHC (P)) | Assay-dependent |
| Immunohistochemistry (PFA fixed) (IHC (PFA)) | 1–2 µg/mL |
| Immunocytochemistry (ICC/IF) | 1–2 µg/mL |
| Flow Cytometry (Flow) | 1–2 µg/10^6 cells |
Product Specifications
| Specification | Description |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Mouse / IgG3, kappa |
| Class | Monoclonal |
| Type | Antibody |
| Clone | DF-B1 |
| Immunogen | Extract from Alexander’s hepatoma cell line L428 (Workshop V) |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Protein A/G |
| Storage Buffer | PBS, pH 7.4 |
| Contains | No preservative |
| Storage Conditions | -20°C, Avoid Freeze/Thaw Cycles |
| Shipping Conditions | Wet ice |
Product Specific Information
Does not react with Rat.
Target Information
CD45RB is a receptor-type protein tyrosine phosphatase of the CD45 glycoprotein family. CD45 plays a crucial role in lymphocyte development and antigen signaling, acting as a regulator of Src-family kinases. It promotes cell survival by modulating integrin-mediated signal transduction and participates in DNA fragmentation during apoptosis.
CD45 isoforms differ in extracellular domains but share identical transmembrane and cytoplasmic domains. Their expression depends on cell type and physiological state.
CD45RB is expressed in microglia and inflammatory cells, and CD45 is broadly expressed in the human hematopoietic lineage except for mature red cells.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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