Thermo Fisher Scientific Phospho-c-ABL (Tyr115) Polyclonal Antibody
Phospho-c-ABL (Tyr115) 폴리클로날 항체로 인간, 마우스, 랫트 시료에서 반응. Western blot, IHC, ICC, ELISA 등 다양한 응용 가능. 고순도 Protein A 정제, 액상 형태로 안정적 보관 (-20°C). 세포 신호전달 및 암 연구용으로 적합.
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Thermo Fisher Scientific Phospho-c-ABL (Tyr115) Polyclonal Antibody
Applications and Tested Dilutions
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1:500–1:2,000 |
| Immunohistochemistry (Paraffin) (IHC (P)) | 1:50–1:200 |
| Immunohistochemistry (Frozen) (IHC (F)) | 1:100–1:500 |
| Immunocytochemistry (ICC/IF) | 1:100–1:500 |
| ELISA | 1:500–1:1,000 |
Product Specifications
| Specification | Description |
|---|---|
| Species Reactivity | Human, Mouse, Rat |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | KLH conjugated synthetic phosphopeptide derived from human c-Abl isoform a around the phosphorylation site of Tyr115 |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Protein A |
| Storage Buffer | 0.01M TBS, pH 7.4, with 1% BSA, 50% glycerol |
| Contains | 0.02% ProClin 300 |
| Storage Conditions | -20°C |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
Target Information
The ABL1 proto-oncogene encodes a cytoplasmic and nuclear protein tyrosine kinase involved in cell differentiation, division, adhesion, and stress response. Activity of c-Abl is negatively regulated by its SH3 domain; deletion of this domain converts c-Abl into an oncogene. The DNA-binding activity of ABL1 is regulated by CDC2-mediated phosphorylation, indicating a role in the cell cycle. In chronic myelogenous leukemia and some acute lymphoblastic leukemias, the c-Abl proto-oncogene undergoes a (9;22) translocation forming the Philadelphia chromosome, fusing c-Abl sequences from chromosome 9 to the Bcr gene on chromosome 22. The c-Abl oncogene was first identified as the viral transforming gene of Abelson murine leukemia virus (A-MuLV). c-Abl may also regulate DNA repair by activating proapoptotic pathways when DNA damage is irreparable.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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