Thermo Fisher Scientific APOBEC3G Polyclonal Antibody
APOBEC3G 단백질을 인식하는 Thermo Fisher Scientific의 토끼 폴리클로날 항체. Western blot 및 IHC에 사용 가능. 인간에 반응하며, 단백질 A로 정제된 액상 포맷. HIV-1 관련 연구 및 세포 내 항바이러스 기전 연구에 적합.
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Applications
| Application | Tested Dilution | Publications |
|---|---|---|
| Western Blot (WB) | 1.0 µg/mL | - |
| Immunohistochemistry (IHC) | Assay-dependent | - |
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Synthetic peptide directed towards the middle region of human APOBEC3G |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1.0 mg/mL |
| Purification | Protein A |
| Storage Buffer | PBS with 2% sucrose |
| Contains | 0.09% sodium azide |
| Storage Conditions | -20°C, Avoid Freeze/Thaw Cycles |
| Shipping Conditions | Wet ice |
| RRID | AB_2689501 |
Product Specific Information
This target displays homology in the following species:
Dog: 93%; Horse: 100%; Human: 100%; Mouse: 86%; Pig: 86%; Rabbit: 93%; Rat: 93%
Target Information
The Apoliprotein B mRNA-editing enzyme-catalytic polypeptide-like (APOBEC) 3 is a multi-isoform member of the cytidine deaminase family of enzymes that act on monomeric nucleoside and nucleotide substrates. Similar to TRIM5α, which targets incoming retroviral capsids, APOBEC3 plays a major role in cellular defense against retroviral infection. At least two isoforms, APOBEC3G and to a lesser extent APOBEC3F, can be incorporated into HIV-1 virions and induce hypermutation in newly synthesized viral DNA, destabilizing the viral genome. This innate retroviral resistance mechanism is counteracted by the HIV-1 Vif protein, which induces ubiquitination and degradation of APOBEC3G; a single amino acid substitution (D128K) blocks APOBEC3G depletion without affecting its inhibitory activity.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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