Thermo Fisher Scientific CXCR5 Polyclonal Antibody
마우스 CXCR5 단백질을 인식하는 염소 유래 폴리클로날 항체로, Flow Cytometry에 적합합니다. 항원 친화 크로마토그래피로 정제되었으며, 동결건조 형태로 제공됩니다. ELISA에서 CXCR7과의 교차 반응성이 1% 미만입니다. 연구용으로만 사용 가능합니다.
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Applications
Flow Cytometry (Flow)
- Tested Dilution: 2.5 µg per million cells
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Mouse |
| Host / Isotype | Goat / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | E. coli-derived recombinant mouse CXCR5 (Met1–Pro57, Glu112–Thr126, Lys191–Phe221, Leu283–Ile306) joined by linker peptides |
| Conjugate | Unconjugated |
| Form | Lyophilized |
| Concentration | 0.2 mg/mL |
| Purification | Antigen affinity chromatography |
| Storage buffer | PBS with 5% trehalose |
| Contains | No preservative |
| Storage conditions | -20°C, Avoid freeze/thaw cycles |
| Shipping conditions | Ambient (domestic); Wet ice (international) |
| RRID | AB_2608130 |
Product Specific Information
- In direct ELISAs, less than 1% cross-reactivity with recombinant mouse CXCR7 is observed.
- Reconstitute at 0.2 mg/mL in sterile PBS.
Target Information
CXCR5 (C-X-Chemokine Receptor Type 5, CD185), also known as Burkitt lymphoma receptor 1 (BLR1), belongs to the CXC chemokine receptor family.
It is a G protein-coupled seven-transmembrane receptor for chemokine BLC and is specifically expressed in Burkitt’s lymphoma and lymphatic tissues such as lymph node follicles and spleen.
CXCR5 plays an essential role in B cell migration. Expression has been reported in human blood, salivary gland, and multiple animal tissues including lymphatic organs, blood, bone marrow, brain, liver, lymph node, skin, spleen, stomach, and tonsil.
G-protein Coupled Receptors (GPCRs) share a structural motif of seven membrane-spanning helices and exist in both active and inactive forms. They are key targets in pharmacological research, with several GPCR-targeted drugs developed for mental health and allergy applications.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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