Thermo Fisher Scientific alpha Synuclein Monoclonal Antibody (4F1), PerCP
알파 시뉴클레인 단백질 검출용 PerCP 결합 단일클론 항체로, Western blot, IHC, ICC, ELISA, Dot blot에 사용 가능. 인간, 마우스, 랫트 반응성. 단백질 G 정제, 보존제 없음, 4°C 보관. 파킨슨병 연구 등 신경퇴행 질환 연구에 적합.
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Applications and Tested Dilutions
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1:1,000 |
| Immunohistochemistry (IHC) | 1:200 |
| Immunocytochemistry (ICC/IF) | 1:100 |
| ELISA | 1:1,000 |
| Dot blot (DB) | 1:1,000 |
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human, Mouse, Rat |
| Host / Isotype | Mouse / IgG1 |
| Class | Monoclonal |
| Type | Antibody |
| Clone | 4F1 |
| Immunogen | Mouse alpha synuclein aggregate |
| Conjugate | PerCP |
| Excitation / Emission Max | 482 / 675 nm |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Protein G |
| Storage Buffer | 95.64 mM phosphate / 2.48 mM MES, pH 7.4, with 0.5 M EDTA |
| Contains | No preservative |
| Storage Conditions | 4°C |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
| RRID | AB_2932302 |
Additional Formats
Product Specific Information
- A 1:1,000 dilution of MA5-45848 was sufficient for detection of Alpha Synuclein in 15 µg of human brain cell lysate by ECL immunoblot analysis using goat anti-mouse IgG:HRP as the secondary antibody.
- Binds multiple linear epitopes within human alpha synuclein: 21–70 aa, 61–90 aa, and 101–140 aa, determined using Dot blot and ELISA with corresponding peptides.
- Detects approximately 14 kDa band corresponding to Alpha synuclein. Band at approximately 40 kDa is a trimer.
Target Information
Alpha-synuclein is a member of the synuclein family, which also includes beta- and gamma-synuclein. These proteins are abundant in the brain and play a role in regulating synaptic transmission and membrane trafficking. Alpha- and beta-synuclein have been shown to selectively inhibit phospholipase D2, suggesting involvement in signaling pathways.
Defects in the SNCA gene, which encodes alpha-synuclein, are implicated in Parkinson’s disease pathogenesis. Alpha-synuclein peptides are major components of amyloid plaques in Alzheimer’s disease. Multiple alternatively spliced transcripts encoding different isoforms have been identified for this gene.
Diseases associated with SNCA include Parkinson Disease 1 (Autosomal Dominant) and Dementia with Lewy Bodies.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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