Thermo Fisher Scientific IL-27 p28 Polyclonal Antibody
IL-27 p28 단백질을 인식하는 Rabbit Polyclonal 항체로, Western blot에 적합합니다. Human 및 Mouse 시료에 반응하며, Protein G로 정제된 0.5 mg/mL 액상 형태입니다. IL-27 관련 면역반응 연구에 유용합니다.
- 카탈로그번호
- PA124498
- 판매단위
- pk
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Applications
Western Blot (WB)
- Tested Dilution: 1–2 µg/mL
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human, Mouse |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | A synthetic peptide corresponding to amino acids 31–46 (RPPGRPQLSLQELRRE) of human IL-27 (p28 subunit), GenBank accession number NP_663634 |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 0.5 mg/mL |
| Purification | Protein G |
| Storage Buffer | PBS with 0.05% BSA |
| Contains | 0.05% sodium azide |
| Storage Conditions | Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles. |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
| RRID | AB_2124948 |
Product Specific Information
Store product as a concentrated solution. Centrifuge briefly prior to opening the vial.
Target Information
IL-27 is a heterodimeric protein belonging to the IL-12 family, composed of the p40-related protein EBI3 and the IL-12p35-related protein p28 (also known as IL-30). It is produced by activated antigen-presenting cells (APCs) and mature dendritic cells.
IL-27 acts on NK cells and naive CD4+ T cells, and may also affect mast cells and monocytes. Binding of IL-27 to WSX-1/gp130 activates JAK1, STAT1, and STAT3, leading to STAT1/3 phosphorylation. WSX-1/TCCR-deficient mice show impaired Th1 responses, indicating IL-27’s importance in initiating Th1 differentiation.
IL-27 induces the Th1-specific transcription factor T-bet and suppresses GATA-3, supporting Th1 lineage commitment. It also exhibits potent antitumor activity by enhancing CTL differentiation and granzyme B expression, inhibiting tumor growth, and promoting regression of neuroblastoma in vivo.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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