Thermo Fisher Scientific SSX4 Polyclonal Antibody
인간 SSX4 단백질을 인식하는 Rabbit Polyclonal 항체. IHC(P)에서 1:100~1:200 희석으로 사용 가능. 항원 친화 크로마토그래피로 정제되었으며, PBS/glycerol buffer에 보관. 암 연구 및 SSX 단백질 발현 분석에 적합.
- 카탈로그번호
- PA550833
- 판매단위
- pk
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Applications
Immunohistochemistry (Paraffin) (IHC (P))
- Tested Dilution: 1:100–1:200
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Synthetic peptide corresponding to residues near the C-terminal of human synovial sarcoma, X breakpoint 4 |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1.1 mg/mL |
| Purification | Antigen affinity chromatography |
| Storage Buffer | PBS, pH 7.4, with 40% glycerol |
| Contains | 0.05% sodium azide |
| Storage Conditions | -20°C |
| Shipping Conditions | Wet ice |
| RRID | AB_2636285 |
Product Specific Information
This antibody detects endogenous levels of total SSX4 protein.
Target Information
SSX4 belongs to the SSX family and contains one KRAB-related domain. It may act as a modulator of transcription.
SSX family proteins, including SSX4, function as transcriptional repressors and can elicit humoral and cellular immune responses in cancer patients, making them potential targets for cancer vaccine-based immunotherapy.
SSX1, SSX2, and SSX4 genes are involved in the t(X;18) translocation characteristic of all synovial sarcomas, resulting in fusion between the synovial sarcoma translocation gene on chromosome 18 and one of the SSX genes on chromosome X.
Chromosome Xp11 contains a segmental duplication resulting in two identical copies of synovial sarcoma, X breakpoint 4 (SSX4 and SSX4B), in tail-to-tail orientation. This gene, SSX4, represents the more telomeric copy. Two transcript variants encoding distinct isoforms have been identified.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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