Thermo Fisher Scientific Creatine Kinase MT Polyclonal Antibody
Rabbit polyclonal antibody against human Creatine Kinase MT. Validated for WB and IHC-P applications. Antigen affinity purified, 1 mg/mL in tris-glycine buffer. Recommended positive controls include 293T, H1299, HeLaS3, HepG2 cells.
- 판매단위
- pk
카탈로그
1개 옵션 · 카탈로그 번호를 클릭하면 복사됩니다Thermo Fisher Scientific · Thermo Fisher Scientific Creatine Kinase MT Polyclonal Antibody
Applications
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1:500–1:3,000 |
| Immunohistochemistry (Paraffin) (IHC-P) | 1:100–1:1,000 |
Product Specifications
| Property | Description |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Recombinant protein fragment containing a sequence corresponding to a region within amino acids 63–287 (P12532) of Creatine Kinase 1B |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Antigen affinity chromatography |
| Storage Buffer | 0.1M Tris glycine, pH 7, with 10% glycerol |
| Contains | 0.01% thimerosal |
| Storage Conditions | Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles. |
| Shipping Conditions | Wet ice |
| RRID | AB_11152886 |
Product Specific Information
- Recommended positive controls: 293T, H1299, HeLaS3, HepG2
- Predicted reactivity: Rat (98%), Xenopus laevis (88%), Rabbit (99%), Bovine (98%)
- Store product as a concentrated solution. Centrifuge briefly prior to opening the vial.
Target Information
Mitochondrial creatine (MtCK) kinase is responsible for the transfer of high-energy phosphate from mitochondria to the cytosolic carrier, creatine. It belongs to the creatine kinase isoenzyme family and exists as two isoenzymes: sarcomeric MtCK and ubiquitous MtCK, encoded by separate genes.
Mitochondrial creatine kinase occurs in two different oligomeric forms—dimers and octamers—in contrast to the exclusively dimeric cytosolic creatine kinase isoenzymes.
Overexpression of ubiquitous mitochondrial creatine kinase has been observed in many malignant cancers with poor prognosis, possibly related to high energy turnover and impaired apoptosis.
Two genes located near each other on chromosome 15 encode identical mitochondrial creatine kinase proteins.
⚠ WARNING: This product can expose you to chemicals including mercury, which is known to the State of California to cause birth defects or other reproductive harm.
For more information, visit www.P65Warnings.ca.gov.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Thermo Fisher Scientific 상품 둘러보기
전체보기
문의
0개 · 배송·재고 문의는 실시간 상담이 빠릅니다아직 등록된 문의가 없어요.