Thermo Fisher Scientific Creatine Kinase MT Polyclonal Antibody

Applications

Product Specifications

Product Specific Information

• Recommended positive controls: 293T, H1299, HeLaS3, HepG2
• Predicted reactivity: Rat (98%), Xenopus laevis (88%), Rabbit (99%), Bovine (98%)
• Store product as a concentrated solution. Centrifuge briefly prior to opening the vial.

Target Information

Mitochondrial creatine (MtCK) kinase is responsible for the transfer of high-energy phosphate from mitochondria to the cytosolic carrier, creatine. It belongs to the creatine kinase isoenzyme family and exists as two isoenzymes: sarcomeric MtCK and ubiquitous MtCK, encoded by separate genes.
Mitochondrial creatine kinase occurs in two different oligomeric forms—dimers and octamers—in contrast to the exclusively dimeric cytosolic creatine kinase isoenzymes.
Overexpression of ubiquitous mitochondrial creatine kinase has been observed in many malignant cancers with poor prognosis, possibly related to high energy turnover and impaired apoptosis.
Two genes located near each other on chromosome 15 encode identical mitochondrial creatine kinase proteins.

⚠ WARNING: This product can expose you to chemicals including mercury, which is known to the State of California to cause birth defects or other reproductive harm.
For more information, visit www.P65Warnings.ca.gov.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.