Thermo Fisher Scientific IL-8 Polyclonal Antibody
IL-8 단백질을 인식하는 Rabbit Polyclonal 항체로, WB, IHC, ICC, ELISA 등 다양한 응용에 사용 가능. Human, Mouse, Rabbit, Rat 반응성. Protein A로 정제된 액상형 항체로, -20°C 보관. 연구용으로만 사용.
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Applications and Tested Dilutions
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1:300–1:1,000 |
| Immunohistochemistry (Paraffin) (IHC (P)) | 1:200 |
| Immunohistochemistry (Frozen) (IHC (F)) | 1:100–1:500 |
| Immunocytochemistry (ICC/IF) | 1:50–1:200 |
| ELISA | 1:500–1:1,000 |
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human, Mouse, Rabbit, Rat |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | KLH conjugated synthetic peptide derived from human IL-8, amino acids 31–99 |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Protein A |
| Storage Buffer | 0.01M TBS, pH 7.4, with 1% BSA, 50% glycerol |
| Contains | 0.02% ProClin 300 |
| Storage Conditions | –20°C |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
Target Information
Interleukin 8 (IL-8, CXCL8) is a 72 amino acid pro-inflammatory factor belonging to the CXC chemokine family. It binds to cell surface receptors IL-8RA and IL-8RB and functions as a chemoattractant and angiogenic factor. IL-8 expression is induced by various inflammatory stimuli in many cell types, including macrophages and endothelial cells, where it is stored in Weibel-Palade bodies. Originally isolated from osteosarcoma cells, IL-8 contains an ELR motif (Glu-Leu-Arg) and signals through CXCR1 and CXCR2 receptors. It has been known by other names such as NAP-1, GCP-1, MONAP, and protein 3-10C. The IL-8 gene is part of a chemokine cluster on chromosome 4q. IL-8 is implicated in tumor angiogenesis and growth, as well as in the pathogenesis of bronchiolitis caused by viral infections.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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