Thermo Fisher Scientific LAP2 Polyclonal Antibody

Thermo Fisher Scientific LAP2 Polyclonal Antibody

Applications and Tested Dilution

Product Specifications

Target Information

In eukaryotic cells, the nuclear envelope consists of inner and outer membranes which define the border between the nucleus and cytoplasm. The inner and outer nuclear membranes are joined by large supramolecular assemblies called nuclear pore complexes, through which various molecules pass into and out of the nucleus. The inner membrane is lined by a filamentous meshwork called the nuclear lamina made up of proteins called lamins. The attachment of the lamins to the inner nuclear membrane occurs through their association with four related integral membrane proteins called Lamin Associated Polypeptides (LAPs). LAP 1A, 1B, and 1C share high sequence homology, while LAP 2 is distinct. LAP 1A/B bind lamins A, C, and B1, while LAP 2 binds lamin B1 only. LAP 2 also binds chromosomes, and phosphorylation during mitosis inhibits binding to both lamins and chromosomes, indicating LAP 2’s role in nuclear envelope reassembly.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.