Thermo Fisher Scientific LAP2 Polyclonal Antibody
LAP2 단백질을 인식하는 Thermo Fisher Scientific의 polyclonal antibody로, WB, IHC, ICC/IF, IP 등 다양한 응용에 적합. 인간 시료 반응성, 고순도 항원 친화 정제, 안정적 액상 형태로 연구용에 최적화됨.
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Thermo Fisher Scientific LAP2 Polyclonal Antibody
Applications and Tested Dilution
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1:500–1:2,000 |
| Immunohistochemistry (Paraffin) (IHC (P)) | 1:50–1:200 |
| Immunocytochemistry (ICC/IF) | 1:100–1:500 |
| Immunoprecipitation (IP) | 5–10 µL/mg of lysate |
Product Specifications
| Specification | Description |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | E. coli-derived Human TMPO fragment |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Antigen affinity chromatography, Protein A |
| Storage Buffer | PBS, pH 7 |
| Contains | 0.03% ProClin 300 |
| Storage Conditions | Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles. |
| Shipping Conditions | Wet ice |
| RRID | AB_2866951 |
Target Information
In eukaryotic cells, the nuclear envelope consists of inner and outer membranes which define the border between the nucleus and cytoplasm. The inner and outer nuclear membranes are joined by large supramolecular assemblies called nuclear pore complexes, through which various molecules pass into and out of the nucleus. The inner membrane is lined by a filamentous meshwork called the nuclear lamina made up of proteins called lamins. The attachment of the lamins to the inner nuclear membrane occurs through their association with four related integral membrane proteins called Lamin Associated Polypeptides (LAPs). LAP 1A, 1B, and 1C share high sequence homology, while LAP 2 is distinct. LAP 1A/B bind lamins A, C, and B1, while LAP 2 binds lamin B1 only. LAP 2 also binds chromosomes, and phosphorylation during mitosis inhibits binding to both lamins and chromosomes, indicating LAP 2’s role in nuclear envelope reassembly.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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