Thermo Fisher Scientific WAC Polyclonal Antibody
Rabbit polyclonal antibody against human WAC protein. Validated for ICC/IF applications. Purified by antigen affinity chromatography. Supplied as liquid in PBS with 40% glycerol. For research use only.
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Applications and Tested Dilution
- Immunocytochemistry (ICC/IF): 0.25–2 µg/mL
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Recombinant Human WAC. Recombinant protein control fragment (Product #RP-106031) |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 0.2 mg/mL |
| Purification | Antigen affinity chromatography |
| Storage Buffer | PBS, pH 7.2, with 40% glycerol |
| Contains | 0.02% sodium azide |
| Storage Conditions | Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles. |
| Shipping Conditions | Wet ice |
| RRID | AB_2664601 |
Product Specific Information
- Immunogen sequence:
NATVVPQNSSA RSTCSLTPAL AAHFSENLIK HVQGWPADHA EKQASRLREE AHNMGTIHMS EICTELKNLR SLVRVCEIQA TLR - Highest antigen sequence identity: Mouse 89%, Rat 88%
Target Information
The WW domain containing adaptor with coiled-coil protein (WAC) includes a WW domain that mediates protein–protein interactions and colocalizes with RNA splicing factor SC35. WAC functions as a partner of the RNF20/40 complex that ubiquitinates Histone H2B and regulates H2B ubiquitination. It targets RNF20/40 to associate with RNA polymerase II complex for H2B ubiquitination at active transcription sites. WAC-dependent transcription is also critical for cell-cycle checkpoint activation in response to genotoxic stress.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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