Thermo Fisher Scientific Septin 2 Polyclonal Antibody
Rabbit polyclonal antibody against human Septin 2. Validated for ICC/IF applications. Recognizes cytoskeletal GTPase involved in mitosis and cell organization. Supplied as liquid, unconjugated form, 0.2 mg/mL in PBS with 40% glycerol. For research use ...
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Applications and Tested Dilution
- Immunocytochemistry (ICC/IF): 0.25–2 µg/mL
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Recombinant Protein Epitope Signature Tag (PrEST) antigen sequence (range: 1–57). Recombinant protein control fragment (Product #RP-110060). |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 0.2 mg/mL |
| Purification | Affinity chromatography |
| Storage Buffer | PBS, pH 7.2, with 40% glycerol |
| Contains | 0.02% sodium azide |
| Storage Conditions | Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles. |
| Shipping Conditions | Wet ice |
| RRID | AB_3092044 |
Product Specific Information
- Immunogen sequence: MPWISEGRAT RPCLRVPSAR RGDEGLHQRD EASQKMSKQQ PTQFINPETP GYVGFAN
- Antigen sequence identity: Mouse 50%; Rat 39%
Target Information
Septin 2 is a filament-forming cytoskeletal GTPase required for normal actin cytoskeleton organization and polarized epithelial cell formation. It maintains polyglutamylated microtubules, facilitates vesicle transport, and prevents MAP4 binding to tubulin. Septin 2 is essential for mitotic progression, forming a scaffold at the mitotic spindle midplane to maintain CENPE localization and ensure chromosome congression. During anaphase, it contributes to chromosome segregation and spindle elongation. Septin 2 also functions in ciliogenesis and collective cell movement.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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