Thermo Fisher Scientific Abraxas Polyclonal Antibody
인간 Abraxas(CCDC98) 단백질을 인식하는 Rabbit IgG 폴리클로날 항체로, WB, IHC, IP 등 다양한 응용에 적합. 항원 친화 크로마토그래피로 정제되었으며, 1 mg/mL 농도의 액상 형태. 4°C 보관, 웻 아이스로 배송.
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Applications
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | Assay-dependent |
| Immunohistochemistry (IHC) | 1:500–1:2,000 |
| Immunohistochemistry (Paraffin) (IHC (P)) | 1:500–1:2,000 |
| Immunoprecipitation (IP) | 5–15 µg/mg lysate |
Product Specifications
| Specification | Description |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Region between residue 400 and 409 of human Abraxas (coiled-coil domain containing 98) |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Antigen affinity chromatography |
| Storage Buffer | Tris citrate/phosphate, pH 7–8 |
| Contains | 0.09% sodium azide |
| Storage Conditions | 4°C |
| Shipping Conditions | Wet ice |
Product Specific Information
- Recommended shelf life: 1 year from date of receipt
- Application Note: For IHC, epitope retrieval with citrate buffer pH 6.0 is recommended for FFPE tissue sections.
Target Information
CCDC98, also known as Abraxas 1, interacts with the BRCA1 protein and recruits RAP80, a ubiquitin-binding protein, to BRCA1. This interaction facilitates the formation of BRCA1 foci in response to DNA damage caused by ionizing radiation.
Both CCDC98 and RAP80 are essential for DNA damage resistance, G2-M checkpoint control, and DNA repair.
Cells lacking either CCDC98 or RAP80 show increased sensitivity to ionizing radiation, although not as severely as BRCA1-depleted cells, suggesting that CCDC98 and RAP80 mediate part of BRCA1’s DNA damage response role.
At least two isoforms of CCDC98 are known to exist.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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