Thermo Fisher Scientific Phospho-FGFR4 (Tyr754) Polyclonal Antibody
FGFR4 단백질의 Tyr754 인산화 형태를 특이적으로 검출하는 폴리클로날 항체입니다. Western blot에 최적화되어 있으며 인간, 마우스, 랫트 시료에 반응합니다. 고순도 친화 크로마토그래피 정제 및 안정한 PBS/glycerol 버퍼로 제공됩니다.
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Applications
Western Blot (WB)
- Tested Dilution: 1:1,000
- Publications: [References not provided]
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human, Mouse, Rat |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | A synthesized peptide derived from human FGFR4 (Phospho-Tyr754) |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Affinity chromatography |
| Storage Buffer | PBS, pH 7.4, with 50% glycerol |
| Contains | 0.02% sodium azide |
| Storage Conditions | -20°C |
| Shipping Conditions | Wet ice |
| RRID | AB_2663146 |
Product Specific Information
Phospho-FGFR4 (Tyr754) Polyclonal Antibody detects endogenous levels of FGFR4 only when phosphorylated at Tyr754.
Target Information
FGFR4 is a member of the FGFR family of receptor tyrosine kinases. This family regulates cellular functions such as angiogenesis, mitogenesis, osteogenesis, myogenesis, carcinogenesis, differentiation, and tissue repair after injury.
FGFR4 is also implicated in diseases including cancer, rheumatoid arthritis, and diabetic retinopathy.
It is required for normal down-regulation of CYP7A1 expression, the rate-limiting enzyme in bile acid synthesis, in response to FGF19. Additionally, FGFR4 plays a role in postnatal lung development and skeletal muscle lineage formation.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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