Thermo Fisher Scientific HIPPI Polyclonal Antibody
HIPPI 단백질을 인식하는 Rabbit Polyclonal 항체로 Western blot, IHC, ICC, ELISA 등에 사용 가능. Human, Mouse, Rat 반응성. Protein A 정제, 1 mg/mL 농도. 세포자멸 및 Hedgehog 신호 관련 연구에 적합.
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Applications and Tested Dilutions
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1:1,000 |
| Immunohistochemistry (Paraffin) (IHC-P) | 1:50–1:200 |
| Immunohistochemistry (Frozen) (IHC-F) | 1:100–1:500 |
| Immunocytochemistry (ICC/IF) | 1:100–1:500 |
| ELISA | 1:500–1:1,000 |
Product Specifications
| Specification | Detail |
|---|---|
| Species Reactivity | Human, Mouse, Rat |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | KLH conjugated synthetic peptide derived from human HIPPI (amino acids 331–429) |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Protein A |
| Storage Buffer | 0.01M TBS, pH 7.4, with 50% glycerol, 1% BSA |
| Contains | 0.02% ProClin 300 |
| Storage Conditions | -20°C |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
Target Information
HIPPI is required for the formation of cilia and plays an indirect role in sonic hedgehog signaling, as cilia are essential for hedgehog pathway activity. It exhibits pro-apoptotic function through interaction with HIP1, recruiting caspase-8 (CASP8) to trigger apoptosis. HIPPI can bind the DNA sequence motif 5'-AAAGACATG-3' found in the promoters of caspase genes such as CASP1, CASP8, and CASP10, suggesting a potential transcriptional regulatory role, though its biological relevance remains unclear.
For Research Use Only.
Not for use in diagnostic procedures. Not for resale without express authorization.
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