Thermo Fisher Scientific Human ZBP1 Synthetic Peptide
인간 ZBP1 단백질의 C-말단 18개 아미노산 서열에 해당하는 합성 펩타이드입니다. PA5-20455 항체의 블로킹 펩타이드로 사용 가능합니다. 액상 형태로 제공되며, PBS(pH 7.2)와 0.1% BSA 포함. 연구용으로만 사용 가능합니다.
- 카탈로그번호
- PEP0572
- 판매단위
- pk
카탈로그
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Applications
Control (Ctrl)
- Assay-dependent
Blocking Assay (BLOCK)
- Assay-dependent
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Class | Synthetic |
| Type | Peptide |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 200 µg/mL |
| Purification | Purified |
| Storage buffer | PBS, pH 7.2, with 0.1% BSA |
| Contains | 0.02% sodium azide |
| Storage conditions | -20°C |
Product Specific Information
This peptide corresponds to 18 amino acids near the carboxy terminus of human ZBP1.
PEP-0572 can be used as a blocking peptide with polyclonal antibody PA5-20455.
Target Information
Z-DNA binding protein 1 (ZBP1) belongs to a family of proteins that contain the Zalpha domain, which binds specifically to left-handed Z-DNA and Z-RNA. ZBP1 was initially identified as a novel gene up-regulated in activated macrophages in mice bearing ascites tumors, suggesting a role in host response in neoplasia.
Recent studies indicate that cytosolic ZBP1 can act similarly to the toll-like receptor TLR9 by detecting cytosolic double-stranded DNA (dsDNA) and triggering the induction of type I interferon and other innate immune responses. Binding of ZBP1 to dsDNA enhances its association with innate immune response proteins such as the IRF3 transcription factor and the serine/threonine kinase TBK1 (NAK). Multiple isoforms of ZBP1 are known to exist.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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