Thermo Fisher Scientific IRF7 Recombinant Rabbit Monoclonal Antibody (23GB2925)
IRF7 단백질을 표적으로 하는 Thermo Fisher의 재조합 토끼 단클론 항체. Western blot, ICC/IF, Flow Cytometry에 적합. 높은 특이성과 재현성을 제공하며 HEK293F 시스템에서 발현된 정제된 액상 형태. 연구용으로만 사용 가능.
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Applications and Tested Dilutions
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1:1,000–1:5,000 |
| Immunocytochemistry (ICC/IF) | 1:1,000 |
| Flow Cytometry (Flow) | 1:2,000 |
Product Specifications
| Specification | Description |
|---|---|
| Species Reactivity | Human, Mouse, Rat |
| Host / Isotype | Rabbit / IgG |
| Expression System | HEK293F |
| Class | Recombinant Monoclonal |
| Type | Antibody |
| Clone | 23GB2925 |
| Immunogen | A synthesized peptide derived from human IRF7 (200–238AA) |
| Conjugate | Unconjugated |
| Form | Liquid |
| Purification | Affinity chromatography |
| Storage Buffer | PBS, pH 7.4, with 50% glycerol |
| Contains | 0.02% sodium azide |
| Storage Conditions | −20°C |
| Shipping Conditions | Wet ice (domestic); Dry ice (international) |
Target Information
Interferons (IFNs) are involved in numerous immune interactions during viral infections and play major roles in the induction and regulation of innate and adaptive antiviral mechanisms. During infection, host-virus interactions signal downstream molecules such as transcription factors like IFN regulatory factor-3 (IRF3), which stimulate transcription of IFN-α/β genes.
IRF7 is known to contribute to transcriptional activation of virus-inducible cellular genes, including interferon beta chain genes. It plays a key role in the innate immune pathway, interacting with Toll-like receptor (TLR) adaptor proteins MyD88 and Tirp/TRAM, functioning as an intermediate in TLR4 and TLR9 signaling. There are at least four differentially spliced isoforms of IRF7, though their functions are not fully established.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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