Thermo Fisher Scientific RASSF1 Monoclonal Antibody (OTI9A5), TrueMAB
인간 RASSF1 단백질을 타겟으로 하는 Mouse IgG1 단클론 항체로, WB 및 ICC/IF에 적합합니다. 무보존제, 동결건조 형태이며 1 mg/mL 농도로 제공됩니다. 암 연구 및 세포주기 조절 관련 연구에 활용 가능합니다.
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Applications
- Western Blot (WB): 1:500
- Immunocytochemistry (ICC/IF): 1:100
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Mouse / IgG1 |
| Class | Monoclonal |
| Type | Antibody |
| Clone | OTI9A5 |
| Immunogen | Full length human recombinant protein of human RASSF1 produced in E. coli |
| Conjugate | Unconjugated |
| Form | Lyophilized |
| Concentration | 1 mg/mL |
| Purification | Affinity chromatography |
| Storage buffer | PBS, pH 7.3, with 8% trehalose |
| Contains | No preservative |
| Storage conditions | -20°C, Avoid Freeze/Thaw Cycles |
| Shipping conditions | Ambient (domestic); Wet ice (international) |
Product Specific Information
For reconstitution, add 100 µL distilled water to achieve a final antibody concentration of approximately 1 mg/mL.
For conjugation experiments, perform an additional desalting step using Zeba Spin Desalting Columns (7K MWCO, 0.5 mL, Product #89882).
Target Information
RASSF1 encodes a protein similar to RAS effector proteins. Loss or altered expression of this gene is associated with various cancers, suggesting its tumor suppressor function. Inactivation correlates with CpG-island promoter hypermethylation. The encoded protein interacts with DNA repair protein XPA and inhibits cyclin D1 accumulation, inducing cell cycle arrest. Seven alternatively spliced transcript variants encoding distinct isoforms have been reported.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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