Thermo Fisher Scientific RASSF1 Monoclonal Antibody (OTI9A5), TrueMAB

Applications

• Western Blot (WB): 1:500
• Immunocytochemistry (ICC/IF): 1:100

Product Specifications

Product Specific Information

For reconstitution, add 100 µL distilled water to achieve a final antibody concentration of approximately 1 mg/mL.
For conjugation experiments, perform an additional desalting step using Zeba Spin Desalting Columns (7K MWCO, 0.5 mL, Product #89882).

Target Information

RASSF1 encodes a protein similar to RAS effector proteins. Loss or altered expression of this gene is associated with various cancers, suggesting its tumor suppressor function. Inactivation correlates with CpG-island promoter hypermethylation. The encoded protein interacts with DNA repair protein XPA and inhibits cyclin D1 accumulation, inducing cell cycle arrest. Seven alternatively spliced transcript variants encoding distinct isoforms have been reported.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.