Thermo Fisher Scientific CSF2 Monoclonal Antibody (OTI10G3), TrueMAB

Applications and Tested Dilution

Product Specifications

Product Specific Information

For reconstitution, add 100 µL distilled water to achieve a final antibody concentration of approximately 1 mg/mL.
For conjugation experiments, perform an additional round of desalting (e.g., Zeba Spin Desalting Columns, 7K MWCO, 0.5 mL, Product #89882).

Target Information

The GM-CSF gene encodes a cytokine that regulates the production, differentiation, and function of macrophages and granulocytes. The active form exists as a homodimer in the extracellular space. This gene is located at chromosome region 5q31, associated with interstitial deletions in the 5q- syndrome and acute myelogenous leukemia.
It is part of a cluster with interleukins 4, 5, and 13, and is involved in promoting tissue inflammation. Elevated cytokine levels, including GM-CSF, have been observed in SARS-CoV-2 patients with acute respiratory distress syndrome. Mice lacking this gene or its receptor develop pulmonary alveolar proteinosis.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.