
Thermo Fisher Scientific VPS37A Polyclonal Antibody
VPS37A 단백질을 인식하는 Rabbit Polyclonal Antibody로, WB, ICC/IF, ELISA 등 다양한 응용에 적합합니다. 인간, 생쥐, 랫트 반응성을 가지며, 고순도의 액상 형태로 제공됩니다. ESCRT-I 복합체 연구 및 세포막 단백질 분류 연구에 활용됩니다.
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Applications
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1:500–1:2,000 |
| Immunocytochemistry (ICC/IF) | 1:50–1:200 |
| ELISA | 1 µg/mL |
Product Specifications
| Specification | Description |
|---|---|
| Species Reactivity | Human, Mouse, Rat |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Recombinant fusion protein containing a sequence corresponding to amino acids 224–397 of human VPS37A (NP_6896282) |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1.81 mg/mL |
| Purification | Affinity Chromatography |
| Storage Buffer | PBS, pH 7.3, with 50% glycerol |
| Contains | 0.02% sodium azide |
| Storage Conditions | −20°C, Avoid Freeze/Thaw Cycles |
| Shipping Conditions | Wet ice |
| RRID | AB_2805710 |
Product Specific Information
Immunogen sequence:
MPDVPDAFPE LSELSVSQLT DMNEQEEVLL EQFLTLPQLK QIITDKDDLV KSIEELARKN LLLEPSLEAK RQTVLDKYEL LTQMKSTFEK KMQRQHELSE SCSASALQAR LKVAAHEAEE ESDNIAEDFL EGKMEIDDFL SSFMEKRTIC HCRRAKEEKL QQAIAMHSQF HAPL
Positive Samples: MCF7, HepG2, Mouse liver
Cellular Location: Late endosome membrane, Nucleus, Peripheral membrane protein
Target Information
This gene belongs to the VPS37 family and encodes a component of the ESCRT-I (endosomal sorting complex required for transport I) protein complex, required for the sorting of ubiquitinated transmembrane proteins into internal vesicles of multivesicular bodies. Expression of this gene is downregulated in hepatocellular carcinoma, and mutations are associated with autosomal recessive spastic paraplegia-53. A related pseudogene has been identified on chromosome 5. Alternatively spliced transcript variants have been found for this gene.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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