Thermo Fisher Scientific VPS37A Polyclonal Antibody

Applications

Tested Dilution

Publications

Western Blot (WB)

1:500-1:2,000

-

Immunocytochemistry (ICC/IF)

1:50-1:200

-

ELISA (ELISA)

1 µg/mL

-

Product Specifications

Species Reactivity

Human, Mouse, Rat

Host/Isotype

Rabbit / IgG

Class

Polyclonal

Type

Antibody

Immunogen

Recombinant fusion protein containing a sequence corresponding to amino acids 224-397 of human VPS37A (NP_6896282) if (typeof window.$mangular === undefined || !window.$mangular) { window.$mangular = {}; } $mangular.antigenJson = \[{targetFamily:VPS37A,uniProtId:Q8NEZ2-1,ncbiNodeId:9606,antigenRange:224-397,antigenLength:397,antigenImageFileName:PA5-89650_VPS37A_Q8NEZ2-1_Rabbit.svg,antigenImageFileNamePDP:PA5-89650_VPS37A_Q8NEZ2-1_Rabbit_PDP.jpeg,sortOrder:1}\]; $mangular.isB2BCMGT = false; $mangular.isEpitopesModalImageMultiSizeEnabled = true;

View immunogen .st0{fill:#FFFFFF;} .st1{fill:#1E8AE7;}

Conjugate

Unconjugated Unconjugated Unconjugated

Form

Liquid

Concentration

1.81 mg/mL

Purification

Affinity Chromatography

Storage buffer

PBS, pH 7.3, with 50% glycerol

Contains

0.02% sodium azide

Storage conditions

-20° C, Avoid Freeze/Thaw Cycles

Shipping conditions

Wet ice

RRID

AB_2805710

Product Specific Information

Immunogen sequence: MPDVPDAFPE LSELSVSQLT DMNEQEEVLL EQFLTLPQLK QIITDKDDLV KSIEELARKN LLLEPSLEAK RQTVLDKYEL LTQMKSTFEK KMQRQHELSE SCSASALQAR LKVAAHEAEE ESDNIAEDFL EGKMEIDDFL SSFMEKRTIC HCRRAKEEKL QQAIAMHSQF HAPL; Positive Samples: MCF7, HepG2, Mouse liver; Cellular Location: Late endosome membrane, Nucleus, Peripheral membrane protein

Target Information

This gene belongs to the VPS37 family, and encodes a component of the ESCRT-I (endosomal sorting complex required for transport I) protein complex, required for the sorting of ubiquitinated transmembrane proteins into internal vesicles of multivesicular bodies. Expression of this gene is downregulated in hepatocellular carcinoma, and mutations in this gene are associated with autosomal recessive spastic paraplegia-53. A related pseudogene has been identified on chromosome 5. Alternatively spliced transcript variants have been found for this gene.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.