Thermo Fisher Scientific CXCL17 Monoclonal Antibody (510614)

Applications

Tested Dilution

Publications

Western Blot (WB)

2 µg/mL

-

Product Specifications

Species Reactivity

Mouse

Host/Isotype

Rat / IgG2b

Class

Monoclonal

Type

Antibody

Clone

510614

Immunogen

E. coli-derived recombinant mouse CXCL17/VCC-1 Ser31-Leu119 if (typeof window.$mangular === undefined || !window.$mangular) { window.$mangular = {}; } $mangular.antigenJson = \[{targetFamily:CXCL17,uniProtId:Q5UW37-1,ncbiNodeId:10090,antigenRange:31-119,antigenLength:119,antigenImageFileName:MA5-24222_CXCL17_Q5UW37-1_Rat.svg,antigenImageFileNamePDP:MA5-24222_CXCL17_Q5UW37-1_Rat_PDP.jpeg,sortOrder:2}\]; $mangular.isB2BCMGT = false; $mangular.isEpitopesModalImageMultiSizeEnabled = true;

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Conjugate

Unconjugated Unconjugated Unconjugated

Form

Lyophilized

Concentration

0.5 mg/mL

Purification

Protein A/G

Storage buffer

PBS with 5% trehalose

Contains

No Preservative

Storage conditions

-20° C, Avoid Freeze/Thaw Cycles

Shipping conditions

Ambient (domestic); Wet ice (international)

RRID

AB_2607447

Product Specific Information

This antibody detects recombinant mouse (rm) CXCL17/VCC-1 in direct ELISAs and Western blots. In direct ELISAs, 50% cross-reactivity with recombinant human CXCL17 is observed/VCC-1.

Reconstitute at 0.5 mg/mL in sterile PBS.

Target Information

CXCL17 is a chemokine that acts as chemoattractant for monocytes, macrophages and dendritic cells. In particular, CXCL17 is a mucosal chemokine that attracts dendritic cells and blood monocytes to the lungs. CXCL17 plays a role in angiogenesis and possibly in the development of tumors. Further, CXCL17 acts as an anti-inflammatory in the stomach and may play a role in the innate defense against infections. CXCL17 also activates the C-X-C chemokine receptor GPR35 to induce a rapid and transient rise in the level of intracellular calcium ions. 4-Cys CXCL17 seems to exhibit much higher chemoattractant potency on monocytes and macrophages than 6-Cys CXCL17. Diseases associated with CXCL17 dysfunction include cholera.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.