Thermo Fisher Scientific UNC13A Polyclonal Antibody
Rabbit 기반의 Polyclonal UNC13A 항체로 인간 UNC13A 재조합 단백질을 면역원으로 사용. 액상 형태로 제공되며 0.05 mg/mL 농도. 단기 4°C, 장기 -20°C 보관 권장. 신경전달 및 분비소포 성숙 연구에 적합.
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Thermo Fisher Scientific UNC13A Polyclonal Antibody
제품 사양
| 항목 | 내용 |
|---|---|
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Recombinant protein corresponding to Human UNC13A |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 0.05 mg/mL |
| Storage Conditions | Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles. |
| Shipping Conditions | Wet ice |
| RRID | AB_2649264 |
Product Specific Information
- Immunogen sequence: QLSEDFDPDE HSLQGSDMED ERDRDSYHSC HSSVSYHKDS PRWDQDEEEL EEDLEDFLEE EE
- Highest antigen sequence identity to the following orthologs:
- Mouse: 84%
- Rat: 39%
Target Information
UNC13A (also known as KIAA1032) belongs to the unc-13 family. It plays a role in vesicle maturation during exocytosis as a target of the diacylglycerol second messenger pathway.
UNC13A is involved in neurotransmitter release by acting in synaptic vesicle priming prior to vesicle fusion and participates in the activity-dependent refilling of the readily releasable vesicle pool (RRP).
It is essential for synaptic vesicle maturation in most excitatory/glutamatergic synapses but not inhibitory/GABA-mediated synapses.
UNC13A also contributes to secretory granule priming in insulin secretion.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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