Thermo Fisher Scientific RFXANK Polyclonal Antibody

Applications

Western Blot (WB)

• Tested Dilution: 1:500–1:2,000

Immunoprecipitation (IP)

• Tested Dilution: 0.5–2 µL/mg of lysate

Product Specifications

Target Information

Major histocompatibility (MHC) class II molecules are transmembrane proteins that play a central role in the development and control of the immune system.
The protein encoded by this gene, along with regulatory factor X-associated protein and regulatory factor-5, forms a complex that binds to the X box motif of certain MHC class II gene promoters and activates their transcription.
Once bound to the promoter, this complex associates with the non-DNA-binding factor MHC class II transactivator, which controls the cell type specificity and inducibility of MHC class II gene expression.
This protein contains ankyrin repeats involved in protein-protein interactions.
Mutations in this gene have been linked to bare lymphocyte syndrome type II, complementation group B.
Two transcript variants encoding different isoforms have been described for this gene, with only one isoform showing activation activity.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.