Thermo Fisher Scientific PIK3C2A Polyclonal Antibody

Applications and Tested Dilution

Product Specifications

Product Specific Information

Immunogen sequence:
PRMPTFPSTE PIYLSLPGQS PYFSYPLTPA TPFHPQGSLP IYRPVVSTDM AKLFDKIAST SEFLKNGKAR TDLEITDSKV SNLQVSPKSE

Target Information

The Class II PI3 kinases, including PIK3C2A, phosphorylate the 3 position of PI or PI4P. Though not as well studied as the Class I PI3 kinases, the Class II enzymes have been linked to diverse, receptor-mediated cellular processes including insulin signaling, neuronal survival, and growth factor signaling.

PI3-kinases play roles in signaling pathways involved in cell proliferation, oncogenic transformation, cell survival, cell migration, and intracellular protein trafficking. This protein contains a lipid kinase catalytic domain as well as a C-terminal C2 domain, characteristic of class II PI3-kinases.

C2 domains act as calcium-dependent phospholipid binding motifs that mediate translocation of proteins to membranes and may also mediate protein-protein interactions. The PI3-kinase activity of this protein is not sensitive to nanomolar levels of the inhibitor wortmannin. This protein can be activated by insulin and may be involved in integrin-dependent signaling.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.