Thermo Fisher Scientific ACVR2A Monoclonal Antibody (C1)
ACVR2A 단백질을 인식하는 Thermo Fisher Scientific의 C1 클론 단일클론 항체입니다. IHC(P) 실험에 적합하며, 인간과 돼지 시료 반응성이 있습니다. 단백질 A/G로 정제된 액상 형태로, 1 mg/mL 농도이며 장기 보관 시 -20°C에서 보관합니다.
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Applications
Immunohistochemistry (Paraffin) (IHC (P))
- Tested Dilution: 5–20 µg/mL
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human, Pig |
| Host / Isotype | Mouse / IgG2b, kappa |
| Class | Monoclonal |
| Type | Antibody |
| Clone | C1 |
| Immunogen | Recombinant Human ACVR2A protein, Ala20–Pro135 (Accession #P27037) |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Protein A/G |
| Storage Buffer | PBS, pH 7.4, with 50% glycerol |
| Contains | 0.05% Proclin 300 |
| Storage Conditions | Store at 4°C (short term). For long-term storage, store at -20°C, avoiding freeze/thaw cycles. |
| Shipping Conditions | Wet ice |
| RRID | AB_3090544 |
Target Information
Activin A receptor kinase (ACVR2A) is a type II member of the TGF-beta family of receptor serine/threonine kinases.
ACVR2A is involved in the activin and myostatin signaling pathway.
(ACVR2A Aliases: ACVR2, ACTRII)
These receptors are transmembrane proteins composed of:
- A ligand-binding extracellular domain with a cysteine-rich region
- A transmembrane domain
- A cytoplasmic domain with predicted serine/threonine specificity
Type I receptors are essential for signaling, while type II receptors are required for ligand binding and type I receptor expression.
Upon ligand binding, type I and II receptors form a stable complex, resulting in phosphorylation of type I receptors by type II receptors.
Type II receptors are considered constitutively active kinases.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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