Thermo Fisher Scientific Human Girdin Synthetic Peptide
인간 Girdin 단백질의 C-말단 16개 아미노산 서열에 해당하는 합성 펩타이드. PA5-20869 항체의 블로킹 펩타이드로 사용 가능. 세포 이동 및 신경세포 발달 관련 연구에 활용. 연구용으로만 사용 가능.
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Applications
Control (Ctrl)
- Assay-dependent
Blocking Assay (BLOCK)
- Assay-dependent
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Class | Synthetic |
| Type | Peptide |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 200 µg/mL |
| Purification | Purified |
| Storage Buffer | PBS, pH 7.2, with 0.1% BSA |
| Contains | 0.02% sodium azide |
| Storage Conditions | -20°C |
Product Specific Information
This peptide corresponds to 16 amino acids near the carboxy terminus of human Girdin.
PEP-0983 can be used as a blocking peptide with polyclonal antibody PA5-20869.
Target Information
Girdin is a Galpha-interacting protein that can enhance the activation of the protein kinase Akt, remodel the actin cytoskeleton, and is thought to be involved in the regulation of cell migration and cancer metastasis.
It has recently been shown that Girdin interacts with Disrupted-in-Schizophrenia 1 (DISC1), a susceptibility gene for major psychiatric disorders. DISC1 is thought to be involved in the migration, positioning, and differentiation of dentate granule cells (DGCs) during development.
Depletion of Girdin or blocking the Girdin-DISC1 interaction results in defects in axonal sprouting in the CA3 region of the hippocampus and overextended migration or mispositioning of DGCs, suggesting that Girdin plays a role in postnatal neurogenesis in the dentate gyrus.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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