Thermo Fisher Scientific SUPT3H Polyclonal Antibody
SUPT3H 단백질을 검출하기 위한 Thermo Fisher Scientific의 Rabbit Polyclonal Antibody. Western blot 및 ICC/IF에 사용 가능하며, 인간 시료에 반응. 고순도 친화 크로마토그래피 정제, 액상 형태로 제공되며 -20°C에서 보관.
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Thermo Fisher Scientific SUPT3H Polyclonal Antibody
Applications and Tested Dilution
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1:500–1:2,000 |
| Immunocytochemistry (ICC/IF) | 1:100–1:500 |
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | A synthesized peptide derived from human SUPT3H (Accession O75486), corresponding to amino acid residues M101–L151 |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Affinity chromatography |
| Storage Buffer | PBS, pH 7.4, with 50% glycerol |
| Contains | 0.02% sodium azide |
| Storage Conditions | -20°C |
| Shipping Conditions | Wet ice |
| RRID | AB_2818180 |
Product Specific Information
Antibody detects endogenous levels of total SUPT3H.
Target Information
The transcription of many RNA polymerase II-dependent genes requires Spt3, a member of the S. cerevisiae SAGA complex. Transcription from delta sequences, the long terminal repeats that flank yeast Ty elements, requires the yeast SPT3 gene.
Spt3 and Spt20 work together to recruit TATA-box binding protein (TBP) to the core promoter, allowing TBP to bind to SAGA-dependent promoters.
Null mutations in the Spt3 gene cause defects in sporulation, diploid filamentous growth, and haploid invasive growth, indicating that Spt3 plays an important role in both mating and developmental pathways in yeast.
At the promoters of some genes including yeast HO, HIS3, and TRP3, Spt3 inhibits binding of TBP, resulting in reduced transcription. This repressive effect can be overcome by another member of the SAGA complex, GCN5, which promotes TBP/TFIIA complex formation via histone acetylation.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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