Thermo Fisher Scientific MGMT (Marker of Suppressor of Mutation and Carcinogenesis) Recombinant Rabbit Monoclonal Antibody (MGMT/8364R)
MGMT 단백질을 표적으로 하는 Thermo Fisher Scientific의 재조합 토끼 단클론 항체. 인간 시료에 반응하며 IHC(P) 및 IHC(PFA) 실험에 적합. 고순도 Protein A/G 정제, 액상 형태로 제공되며 -20°C 보관 권장.
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Applications and Tested Dilution
| Application | Tested Dilution |
|---|---|
| Immunohistochemistry (Paraffin) (IHC (P)) | 2 µg/mL |
| Immunohistochemistry (PFA fixed) (IHC (PFA)) | 1–2 µg/mL |
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Rabbit / IgG, kappa |
| Expression System | HEK293 cells |
| Class | Recombinant Monoclonal |
| Type | Antibody |
| Clone | MGMT/8364R |
| Immunogen | Recombinant fragment (around aa1–100) of human MGMT |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Protein A/G |
| Storage Buffer | PBS, pH 7.4 |
| Contains | No preservative |
| Storage Conditions | -20°C, Avoid freeze/thaw cycles |
| Shipping Conditions | Wet ice |
Target Information
O6-Methylguanine-DNA Methyltransferase (MGMT) is an important DNA repair protein involved in tumor cell resistance to the cytostatic activity of chemotherapeutic alkylating agents. This protein also protects normal cells against the genotoxic and carcinogenic effects of DNA alkylation. The alkylating drug resistance is caused by MGMT's ability to remove DNA alkyl groups introduced in the O6 position of guanine. MGMT is expressed in variable amounts depending on cell and tissue type, species, and cellular growth characteristics. MGMT activity also varies among tumor groups and within a particular tumor type.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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