Thermo Fisher Scientific GPLD1 Polyclonal Antibody
Western blot 및 IHC(P)에서 사용 가능한 GPLD1 폴리클로날 항체. 사람, 마우스, 랫트 반응성. Protein A 정제 및 1 mg/mL 농도의 액상 형태. GPLD1 단백질 연구용으로 적합하며, -20°C 보관.
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Applications and Tested Dilution
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1:500–1:2,000 |
| Immunohistochemistry (Paraffin) (IHC (P)) | 1:100–1:500 |
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human, Mouse, Rat |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | KLH conjugated synthetic peptide derived from human GPLD1/GPI-PLD |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Protein A |
| Storage Buffer | 0.01M TBS, pH 7.4, with 1% BSA, 50% glycerol |
| Contains | 0.02% ProClin 300 |
| Storage Conditions | -20°C |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
Target Information
GPLD1 is expressed in numerous tissues and cells and specifically cleaves GPI-anchored proteins. The liver has the highest level of GPI-PLD expression and is the primary organ contributing to GPLD1 in the serum. GPLD1 is abundant in serum, where it associates with apolipoproteins AI and AIV. Increased serum GPLD1 is associated with insulin resistance and elevated serum triglycerides.
Many surface proteins are attached to eukaryotic cell membranes via glycosylphosphatidylinositol (GPI) anchors that are covalently bound to the C-terminus of the protein. Cleavage of the GPI moiety by GPLD1, the only enzyme known to cleave the GPI anchor, may regulate attachment of these proteins to the cell surface or their release into the extracellular environment.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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