Thermo Fisher Scientific Thymidylate synthase Polyclonal Antibody
인간, 생쥐, 랫트 반응성을 가진 Thymidylate synthase 폴리클로날 항체로, WB, IHC, ICC, ELISA 등 다양한 응용에 적합. KLH 결합 합성 펩타이드(aa 65–160)로부터 제작되었으며 Protein A로 정제된 액상 항체. DNA 생합성 관련 연구용으로 사용.
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Thermo Fisher Scientific Thymidylate synthase Polyclonal Antibody
Applications and Tested Dilutions
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1:1,000 |
| Immunohistochemistry (Paraffin) (IHC (P)) | 1:200–1:400 |
| Immunohistochemistry (Frozen) (IHC (F)) | 1:100–1:500 |
| Immunocytochemistry (ICC/IF) | 1:50–1:200 |
| ELISA | 1:500–1:1,000 |
Product Specifications
| Property | Description |
|---|---|
| Species Reactivity | Human, Mouse, Rat |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | KLH conjugated synthetic peptide derived from human Thymidylate synthase (TS), amino acids 65–160 |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Protein A |
| Storage Buffer | 0.01M TBS, pH 7.4, with 50% glycerol, 1% BSA |
| Contains | 0.02% ProClin 300 |
| Storage Conditions | -20°C |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
Target Information
Thymidylate Synthase (TS) catalyzes the conversion of deoxyuridine monophosphate (dUMP) to deoxythymidine monophosphate (dTMP), a key step in DNA biosynthesis. TS is a major target for fluoropyrimidine-based antineoplastic drugs such as 5-fluorouracil (5-FU) and fluorodeoxyuridine. These compounds are converted in tumor cells to FdUMP, which inactivates TS by forming a ternary covalent complex with the folate cofactor 5,10-methylenetetrahydrofolate. TS expression correlates with response to 5-FU in colorectal, gastric, head and neck, and breast carcinomas.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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