Thermo Fisher Scientific Kaiso Polyclonal Antibody
Rabbit polyclonal antibody targeting human Kaiso (ZBTB33) for IHC and ICC/IF applications. Recognizes both methylated and non-methylated DNA-binding forms. Purified by antigen affinity chromatography and supplied as liquid form for research use only.
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Applications
Immunohistochemistry (Paraffin) (IHC (P))
- Tested Dilution: 1:200–1:500
Immunocytochemistry (ICC/IF)
- Tested Dilution: 0.25–2 µg/mL
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Recombinant protein corresponding to Human ZBTB33 (Kaiso). Recombinant protein control fragment (Product #RP-91976). |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 0.2 mg/mL |
| Purification | Antigen affinity chromatography |
| Storage Buffer | PBS, pH 7.2, with 40% glycerol |
| Contains | 0.02% sodium azide |
| Storage Conditions | Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles. |
| Shipping Conditions | Wet ice |
| RRID | AB_2789374 |
Product Specific Information
Immunogen sequence:
SSSPDSAVSN TSLVPQADTS QNTSFDGSLI QKMQIPTLLQ EPLSNSLKIS DIITRNTNDP GVGSKHLMEG QKIITLDTAT EIEGLSTGCK VYANIGEDTY DIVIPVKDDP DEGEARLEN
Target Information
This gene encodes a transcriptional regulator with bimodal DNA-binding specificity, binding to both methylated CGCG and non-methylated KAISO-binding site (TCCTGCNA).
It contains an N-terminal POZ/BTB domain and three C-terminal zinc finger motifs.
Kaiso recruits the N-CoR repressor complex to promote histone deacetylation and repressive chromatin formation in target gene promoters.
It may repress Wnt signaling target genes or activate transcription via catenin delta-2 (CTNND2) recruitment.
Interaction with catenin delta-1 (CTNND1) inhibits DNA binding.
Kaiso also interacts with Importin-alpha 2 (karyopherin alpha2), mediating nuclear import.
Alternatively spliced transcript variants encoding the same protein have been identified.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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