Thermo Fisher Scientific MYH9 Polyclonal Antibody

Applications

Western Blot (WB)

• Tested Dilution: 0.3–1 µg/mL

Product Specifications

Product Specific Information

This antibody is tested in Peptide ELISA: antibody detection limit dilution 1:32,000.

Target Information

The MYH9 gene, located on chromosome 22q12.3, encodes the heavy chain of non-muscle myosin IIA (NMHC IIA), a critical component of the actin cytoskeleton that plays essential roles in various cellular processes.
Structurally, the MYH9 gene spans over 106 kilobases and includes 41 exons that translate into a protein of 1,960 amino acids.
This protein forms part of a hexameric complex consisting of two heavy chains, two regulatory light chains, and two essential light chains.
NMHC IIA interacts with actin filaments and contributes to cell migration, adhesion, division, and maintenance of cell shape.

Mutations in MYH9 lead to MYH9-related diseases (MYH9-RD), including May-Hegglin anomaly, Fechtner syndrome, and Epstein syndrome.
These disorders are characterized by macrothrombocytopenia and may cause hearing loss, renal failure, and cataracts later in life.
MYH9 is also essential for hematopoiesis, with its proper function required for hematopoietic stem and progenitor cell maintenance.
Loss of function results in severe blood cell deficiencies and bone marrow failure.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

제품 이미지

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