Thermo Fisher Scientific MYH9 Polyclonal Antibody
Human 및 Mouse 반응성의 MYH9 폴리클로날 항체로 Western blot과 Peptide ELISA에 사용 가능. Goat IgG 기반 비결합 항체로 액상 형태, 0.5 mg/mL 농도. 세포 이동, 접착, 분열 관련 MYH9 단백질 연구에 적합.
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Applications
Western Blot (WB)
- Tested Dilution: 0.3–1 µg/mL
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human, Mouse |
| Host / Isotype | Goat / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Peptide with sequence C-DQINTDLNLERSH |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 0.5 mg/mL |
| Purification | Ammonium sulfate precipitation |
| Storage Buffer | TBS, pH 7.3, with 0.5% BSA |
| Contains | 0.02% sodium azide |
| Storage Conditions | -20°C, Avoid Freeze/Thaw Cycles |
| Shipping Conditions | Wet ice |
| RRID | AB_2933074 |
Product Specific Information
This antibody is tested in Peptide ELISA: antibody detection limit dilution 1:32,000.
Target Information
The MYH9 gene, located on chromosome 22q12.3, encodes the heavy chain of non-muscle myosin IIA (NMHC IIA), a critical component of the actin cytoskeleton that plays essential roles in various cellular processes.
Structurally, the MYH9 gene spans over 106 kilobases and includes 41 exons that translate into a protein of 1,960 amino acids.
This protein forms part of a hexameric complex consisting of two heavy chains, two regulatory light chains, and two essential light chains.
NMHC IIA interacts with actin filaments and contributes to cell migration, adhesion, division, and maintenance of cell shape.
Mutations in MYH9 lead to MYH9-related diseases (MYH9-RD), including May-Hegglin anomaly, Fechtner syndrome, and Epstein syndrome.
These disorders are characterized by macrothrombocytopenia and may cause hearing loss, renal failure, and cataracts later in life.
MYH9 is also essential for hematopoiesis, with its proper function required for hematopoietic stem and progenitor cell maintenance.
Loss of function results in severe blood cell deficiencies and bone marrow failure.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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(이미지 파일명: PA5-142426_MYH9_P35579-1_Goat.svg, PA5-142426_MYH9_P35579-1_Goat_PDP.jpeg)
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