Thermo Fisher Scientific CLCN1 Polyclonal Antibody
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CLCN1 단백질을 인식하는 Thermo Fisher Scientific의 Rabbit Polyclonal 항체로, WB와 IHC에 사용 가능. Mouse와 Rat 반응성. 동결건조 형태로 제공되며, 재구성 후 사용. 골격근에서 높은 발현을 보이는 CLCN1 연구에 적합.
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Applications and Tested Dilution
| Application | Tested Dilution | Publications |
|---|---|---|
| Western Blot (WB) | 1:300–1:2,000 | - |
| Immunohistochemistry (IHC) | 1:300–1:2,000 | - |
| Miscellaneous PubMed (Misc) | - | View 3 publications |
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Mouse, Rat |
| Published Species | Not Applicable |
| Host / Isotype | Rabbit / Ig |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | A synthetic peptide from the C-terminal region of mouse Chloride channel protein 1 (CLCN1) conjugated to an immunogenic carrier protein. |
| Conjugate | Unconjugated |
| Form | Lyophilized |
| Concentration | Not Determined |
| Storage Buffer | Whole serum |
| Contains | No preservative |
| Storage Conditions | Store at 4°C short term. For long-term storage, store at -20°C, avoiding freeze/thaw cycles. Glycerol (1:1) may be added for stability. |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
Product Specific Information
- Reconstitute in 100 µL of sterile water.
- Centrifuge to remove any insoluble material.
- Specificity: CLCN1.
Target Information
The family of voltage-dependent chloride channels (CLCs) regulate cellular trafficking of chloride ions, which are essential for cellular excitability, solute transport, and volume maintenance.
- CLCN1 is highly expressed in skeletal muscle. Mutations in CLCN1 cause myotonia, characterized by muscle stiffness and renal salt wasting.
- CLCN2 is expressed in epithelial tissues such as lung and may be a therapeutic target for cystic fibrosis.
- CLCN3 is abundant in neuronal tissue.
- CLCN4 is found in skeletal, cardiac muscle, and brain.
- CLCN5 mutations cause Dent’s disease (proteinuria, hypercalciuria).
- CLCN6 and CLCN7 are broadly expressed in testis, kidney, brain, and muscle.
For Research Use Only.
Not for use in diagnostic procedures. Not for resale without express authorization.
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