Thermo Fisher Scientific DUSP22 Polyclonal Antibody
Human DUSP22 단백질을 인식하는 Rabbit Polyclonal 항체로, IHC(P)에서 1:50–1:200 희석으로 사용 가능. 항원 친화 크로마토그래피로 정제되었으며, PBS(40% glycerol) 용액 형태로 제공. 내인성 DUSP22/JSP1 단백질 검출에 적합.
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Applications
Immunohistochemistry (Paraffin) [IHC (P)]
- Tested Dilution: 1:50–1:200
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Full length fusion protein of Human DUSP22 (UniProt ID: Q9NRW4-1, amino acids 1–184) |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 3 mg/mL |
| Purification | Antigen affinity chromatography |
| Storage Buffer | PBS, pH 7.4, with 40% glycerol |
| Contains | 0.05% sodium azide |
| Storage Conditions | -20°C |
| Shipping Conditions | Wet ice |
| RRID | AB_2635674 |
Product Specific Information
This antibody detects endogenous levels of total DUSP22 (also known as JSP1) protein.
Target Information
Mitogen-activated protein (MAP) kinases are involved in cellular signal transduction pathways activated by various stimuli. Dual specificity phosphatases (DSPs), including DUSP22, are part of the protein tyrosine phosphatase (PTP) family and selectively dephosphorylate phosphothreonine and phosphotyrosine residues within MAP kinases. DSP expression is induced by growth factors and cellular stress, serving as a negative regulator of MAPK/ERK, SAPK/JNK, and p38 pathways. DUSP22 specifically dephosphorylates ERK2 and JNK and shows highest expression in thymus, with detectable levels in monocytes and lymphocytes.
For Research Use Only.
Not for use in diagnostic procedures. Not for resale without express authorization.
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