Thermo Fisher Scientific RNF168 Polyclonal Antibody
RNF168 단백질을 인식하는 Rabbit Polyclonal Antibody로, Western blot에 최적화되어 있습니다. 인간 및 생쥐 시료에 반응하며, 항원 친화 크로마토그래피로 정제되었습니다. RNF168 단백질 연구 및 DNA 손상 복구 기전 연구에 적합합니다.
- 카탈로그번호
- PA520738
- 판매단위
- pk
카탈로그
1개 옵션 · 카탈로그 번호를 클릭하면 복사됩니다Thermo Fisher Scientific · Thermo Fisher Scientific RNF168 Polyclonal Antibody
Applications
Western Blot (WB)
- Tested Dilution: 1 µg/mL
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human, Mouse |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | An 18 amino acid peptide from near the carboxy terminus of human RNF168 |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Antigen affinity chromatography |
| Storage Buffer | PBS |
| Contains | 0.02% sodium azide |
| Storage Conditions | Maintain refrigerated at 2–8°C for up to 3 months. For long term storage, store at -20°C. |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
| RRID | AB_11153291 |
Product Specific Information
- A suggested positive control is human brain tissue lysate.
- PA5-20738 can be used with blocking peptide PEP-0852.
Target Information
RNF168 is a chromatin-associated RING finger protein functioning as a ubiquitin ligase both in vitro and in vivo. It targets histones H2A and H2AX, forming K63 polyubiquitin chains. Upon DNA double-strand breaks, RNF168 is recruited to damage sites, co-localizing with γH2AX and 53BP1 in an RNF8-dependent manner. This process facilitates retention of 53BP1 and BRCA1, promoting downstream signaling in genome maintenance. At least three isoforms of RNF168 are known to exist.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Thermo Fisher Scientific 상품 둘러보기
전체보기
문의
0개 · 배송·재고 문의는 실시간 상담이 빠릅니다아직 등록된 문의가 없어요.