Thermo Fisher Scientific Tet Polyclonal Antibody
Fruit fly Tet 단백질을 인식하는 Rabbit Polyclonal Antibody로 Western Blot 및 ELISA에 사용 가능. 고순도 Affinity chromatography로 정제된 액상 형태. 안정적인 PBS/glycerol buffer에 보존되며 연구용으로 적합.
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- PA5144574
- 판매단위
- pk
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Applications
Western Blot (WB)
- Assay-dependent
ELISA
- Assay-dependent
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Fruit fly |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Recombinant Fruit fly Tet protein (2494-2767aa) |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 2.808 mg/mL |
| Purification | Affinity chromatography |
| Storage Buffer | PBS, pH 7.4, with 50% glycerol |
| Contains | 0.03% Proclin 300 |
| Storage Conditions | -20°C or -80°C if preferred |
| Shipping Conditions | Wet ice |
| RRID | AB_3091668 |
Target Information
Dioxygenase that specifically demethylates DNA methylated on the 6th position of adenine (N(6)-methyladenosine) DNA (PubMed:25936838, PubMed:30078725).
N(6)-methyladenosine (m6A) DNA is present at a relatively high level at the very earliest embryonic stages but at low levels at the late embryonic stages and may act as a regulator of gene expression (PubMed:25936838).
Promotes differentiation of early germ cells in ovary (PubMed:25936838).
Contributes to neuronal morphology, development, and function in the brain (PubMed:30078725).
By interacting with histone modifier wds, binds to a specific set of genes, modulates intragenic (N(6)-methyladenosine) DNA levels and thereby maintains transcriptional activation (PubMed:30078725).
Also able to catalyze the conversion of the modified genomic base 5-methylcytosine (5mC) into 5-hydroxymethylcytosine (5hmC) (PubMed:25936838).
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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