Thermo Fisher Scientific GeneBLAzer CysLT2-NFAT-bla CHO-K1 Cells
인간 CysLT2 수용체를 안정적으로 발현하는 CHO-K1 기반 NFAT-bla 리포터 세포주로, GPCR 활성 및 항천식 약물 타겟 연구에 적합합니다. 베타-락타마제 리포터를 이용한 형광 검출 및 FRET 분석에 활용됩니다.
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Thermo Fisher Scientific GeneBLAzer™ CysLT2-NFAT-bla CHO-K1 Cells
GeneBLAzer™ CysLT2-NFAT-bla CHO-K1 cells contain the human cysteinyl receptor (CysLT2) stably integrated into the CellSensor™ NFAT-bla CHO-K1 cell line.
CellSensor™ NFAT-bla CHO-K1 cells (Cat. No. K1534) include a beta-lactamase reporter gene under control of the Nuclear Factor of Activated T-cells (NFAT) response element.
These cells are functionally validated for Z′ and EC50 concentrations of LTD4 and tested for assay performance under variable conditions.
Validation and assay performance data are available in the Validation & Assay Performance Summary.
Cysteinyl leukotrienes are involved in the pathophysiology of inflammatory disorders such as chronic asthma. The cysteinyl leukotriene receptors CysLT1 and CysLT2 are key targets for anti-asthma drug development.
Leukotriene receptor antagonists (LTRAs) such as montelukast, zafirlucast, and pranlukast block cysteinyl leukotriene activity, reducing allergic inflammation and asthma symptoms.
For academic pricing, please login or contact us at discoverysciences@invitrogen.com.
제품 사양
| 항목 | 내용 |
|---|---|
| 등록 번호 | NM_020377.2 |
| 어세이 입력 | Cell-based beta lactamase reporter gene |
| 셀 상태 | Dividing Cells |
| 검출 방법 | Fluorescence |
| 용도(애플리케이션) | FRET |
| 유전자 기호 | CysLT2 |
| 개체군 상태 | Single Cell Clone Origin |
| 제품라인 | GeneBLAzer™ |
| 수량 | 2 × 10⁶ cells |
| 리포터 유전자 | BLA (Beta-Lactamase) |
| 타겟 입력 | CysLT2 |
| 세포주 | CHO-K1 |
| System Type | GeneBLAzer™ |
| Druggable Target | GPCR |
| Unit Size | Each |
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