Thermo Scientific™

GeneBLAzer™ CysLT2-NFAT-bla CHO-K1 Cells

GeneBLAzer™ CysLT2-NFAT-bla CHO-K1 cells contain the human Cysteinyl receptor (CysLT2) stably integrated into the CellSensor™ NFAT-bla CHO-K1 cell line. CellSensor™자세히 알아보기

GeneBLAzer™ CysLT2-NFAT-bla CHO-K1 cells contain the human Cysteinyl receptor (CysLT2) stably integrated into the CellSensor™ NFAT-bla CHO-K1 cell line. CellSensor™ NFAT-bla CHO-K1 cells (Cat. no. K1534) contain a beta-lactamase reporter gene under control of the Nuclear Factor of Activated T-cells (NFAT) response element.

The GeneBLAzer™ CysLT2-NFAT-bla CHO-K1 cells are functionally validated for Z` and EC50 concentrations of LTD4. In addition, GeneBLAzer™ CysLT2-NFAT-bla CHO-K1 cells have been tested for assay performance under variable conditions. These data are found in the Validation & Assay Performance Summary.

Cysteinyl leukotrienes play a role in the patho-physiology of numerous inflammatory disorders, including chronic asthmatic inflammation. The cysteine leukotriene receptors, CysLT1 and CysLT2, are thus primary targets for anti-asthma drugs. A number of cysteinyl leukotrienes (including LTC4, LTD4, and LTE4) have been identified, and are known to function as inflammatory mediators as well as being potent smooth muscle contractile agents.

Leukotriene receptor antagonists (LTRAs) reduce the effect of allergic inflammation and athsma by blocking cysteine leukotriene activity. Several CysLT antagonists, such as montelukast, zafirlucast, and pranlukast, are currently used in the treatment of asthma.

For Academic pricing please login or contact us at discoverysciences@invitrogen.com.

사양

등록 번호NM_020377.2

어세이 입력Cell-based beta lactamase reporter gene

셀 상태Dividing Cells

검출 방법Fluorescence

용도(애플리케이션)FRET

유전자 기호CysLT2

개체군 상태Single Cell Clone Origin

제품라인GeneBLAzer™

수량2 x 106 cells

리포터 유전자BLA (Beta-Lactamase)

타겟 입력CysLT2

세포주CHO-K1

System TypeGeneBLAzer™

Druggable TargetGPCR

Unit SizeEach