Thermo Fisher Scientific XBP1 Monoclonal Antibody (3H1G4)
XBP1 단백질을 표적으로 하는 Thermo Fisher Scientific의 단클론 항체(3H1G4)로, Human, Mouse, Rat 시료에 반응합니다. Western blot 및 ICC/IF에 사용 가능하며, 단백질 A로 정제된 액상 항체로 -20°C에서 보관합니다. 연구용으로만 사용됩니다.
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Applications
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1 µg/mL |
| Immunocytochemistry (ICC/IF) | 2–5 µg/mL |
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human, Mouse, Rat |
| Host / Isotype | Mouse / IgG1 |
| Class | Monoclonal |
| Type | Antibody |
| Clone | 3H1G4 |
| Immunogen | Recombinant protein corresponding to amino acids 2–160 of human XBP-1 |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Protein A |
| Storage Buffer | PBS |
| Contains | 0.02% sodium azide |
| Storage Conditions | -20°C |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
| RRID | AB_11157056 |
Product Specific Information
A suggested positive control is XBP-1 recombinant protein.
Target Information
XBP1 encodes a transcription factor that regulates MHC class II genes by binding to a promoter element referred to as an X box. This gene product is a bZIP protein that also acts as a cellular transcription factor binding to an enhancer in the promoter of the T cell leukemia virus type 1. It may enhance viral protein expression by partnering with a viral transactivator.
Under ER stress, the XBP1 mRNA undergoes unconventional splicing mediated by IRE1, removing 26 nucleotides and producing the active isoform XBP1(S). The unspliced isoform XBP1(U) functions as a negative feedback regulator of XBP1(S), modulating transcription during recovery from ER stress. A pseudogene of XBP1 is localized to chromosome 5.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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